Dysregulation of leukocyte trafficking in ageing: Causal factors and possible corrective therapies.
Ageing
Inflammageing
Leukocyte
Senescence
Therapies
Trafficking
Journal
Pharmacological research
ISSN: 1096-1186
Titre abrégé: Pharmacol Res
Pays: Netherlands
ID NLM: 8907422
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
18
08
2020
revised:
24
11
2020
accepted:
27
11
2020
pubmed:
5
12
2020
medline:
19
11
2021
entrez:
4
12
2020
Statut:
ppublish
Résumé
Ageing is a universal biological phenomenon that is accompanied by the development of chronic, low-grade inflammation and remodelling of the immune system resulting in compromised immune function. In this review, we explore how the trafficking of innate and adaptive immune cells under homeostatic and inflammatory conditions is dysregulated in ageing. We particularly highlight the age-related changes in the expression of adhesion molecules and chemokine receptor/ligands, and the accumulation of senescent cells that drive modulated leukocyte trafficking. These age-related changes to leukocyte trafficking are multifactorial and specific to leukocyte subset, tissue, type of vascular bed, and inflammatory status. However, dysregulated leukocyte trafficking ultimately affects immune responses in older adults. We therefore go on to discuss approved drugs, including anti-integrins, anti-chemokines and statins, as well as novel therapeutics that may be used to target dysregulated leukocyte trafficking in ageing, improve immune responses and delay the onset of age-related diseases.
Identifiants
pubmed: 33276099
pii: S1043-6618(20)31631-5
doi: 10.1016/j.phrs.2020.105323
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
105323Subventions
Organisme : Department of Health
Pays : United Kingdom
Informations de copyright
Crown Copyright © 2020. Published by Elsevier Ltd. All rights reserved.