M Chimen

Affiliations

MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Wolfson Drive, Birmingham, B15 2TT, United Kingdom. Electronic address: m.chimen@bham.ac.uk.

Publications (16)

Dysregulation of leukocyte trafficking in ageing: Causal factors and possible corrective therapies.

Pharmacological research

Avec: S Hopkin , J M Lord , M Chimen

Triggering the Resolution of Immune Mediated Inflammatory Diseases: Can Targeting Leukocyte Migration Be the Answer?

Frontiers in pharmacology

Avec: Sophie J Hopkin , Jonathan W Lewis , Franziska Krautter , Myriam Chimen , Helen M McGettrick

Nanoscale clustering of mycobacterial ligands and DC-SIGN host receptors are key determinants for pathogen recognition.

Science advances

Avec: Albertus Viljoen , Alain Vercellone , Myriam Chimen , Gérald Gaibelet , Serge Mazères , Jérôme Nigou , Yves F Dufrêne

Preclinical characterization of ISB 1342, a CD38 × CD3 T-cell engager for relapsed/refractory multiple myeloma.

Blood

Avec: Blandine Pouleau , Carole Estoppey , Perrine Suere , Emilie Nallet , Amélie Laurendon , Thierry Monney , Daniela Pais Ferreira , Adam Drake , Laura Carretero-Iglesia , Julie Macoin , Jérémy Berret , Maria Pihlgren , Marie-Agnès Doucey , Girish S Gudi , Vinu Menon , Venkatesha Udupa , Abhishek Maiti , Gautam Borthakur , Ankita Srivastava , Stanislas Blein , M Lamine Mbow , Thomas Matthes , Zeynep Kaya , Claire M Edwards , James R Edwards , Emmanuelle Menoret , Charlotte Kervoëlen , Catherine Pellat-Deceunynck , Philippe Moreau , Eugene Zhukovsky , Mario Perro , Myriam Chimen

Appropriation of GPIbα from platelet-derived extracellular vesicles supports monocyte recruitment in systemic inflammation.

Haematologica

Avec: Myriam Chimen , Aigli Evryviadou , Clare L Box , Matthew J Harrison , Jon Hazeldine , Lea H Dib , Sahithi J Kuravi , Holly Payne , Joshua M J Price , Dean Kavanagh , Asif J Iqbal , Sian Lax , Neena Kalia , Alex Brill , Steve G Thomas , Antonio Belli , Nicholas Crombie , Rachel A Adams , Shelley-Ann Evans , Hans Deckmyn , Janet M Lord , Paul Harrison , Steve P Watson , Gerard B Nash , G Ed Rainger

Characterisation of endogenous Galectin-1 and -9 expression in monocyte and macrophage subsets under resting and inflammatory conditions.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Avec: Franziska Krautter , Carlota Recio , Mohammed T Hussain , Danielle R Lezama , Francesco Maione , Myriam Chimen , Asif J Iqbal

Therapeutic avenues in bone repair: Harnessing an anabolic osteopeptide, PEPITEM, to boost bone growth and prevent bone loss.

Cell reports. Medicine

Avec: Jonathan W Lewis , Kathryn Frost , Georgiana Neag , Mussarat Wahid , Melissa Finlay , Ellie H Northall , Oladimeji Abudu , Edward T Davis , Emily Powell , Charlotte Palmer , Jinsen Lu , G Ed Rainger , Asif J Iqbal , Myriam Chimen , Ansar Mahmood , Simon W Jones , James R Edwards , Amy J Naylor , Helen M McGettrick

Rejuvenation of leukocyte trafficking in aged mice through PEPITEM intervention.

npj aging

Avec: Sophie J Hopkin , Poppy Nathan , Laleh Pezhman , Jenefa Begum , Julia E Manning , Lauren M Quinn , G Ed Rainger , Helen M McGettrick , Asif J Iqbal , Myriam Chimen

PEPITEM modulates leukocyte trafficking to reduce obesity-induced inflammation.

Clinical and experimental immunology

Avec: Laleh Pezhman , Sophie J Hopkin , Jenefa Begum , Silke Heising , Daniela Nasteska , Mussarat Wahid , G Ed Rainger , David J Hodson , Asif J Iqbal , Myriam Chimen , Helen M McGettrick

Aging modulates homeostatic leukocyte trafficking to the peritoneal cavity in a sex-specific manner.

Journal of leukocyte biology

Avec: Sophie J Hopkin , Laleh Pezhman , Jenefa Begum , Dean Kavanagh , Helen M McGettrick , Asif J Iqbal , Myriam Chimen

Local steroid activation is a critical mediator of the anti-inflammatory actions of therapeutic glucocorticoids.

Annals of the rheumatic diseases

Avec: Chloe Fenton , Claire Martin , Rachel Jones , Adam Croft , Joana Campos , Amy J Naylor , Angela E Taylor , Myriam Chimen , Mark Cooper , Gareth G Lavery , Karim Raza , Rowan S Hardy

Dysregulation of Leukocyte Trafficking in Type 2 Diabetes: Mechanisms and Potential Therapeutic Avenues.

Frontiers in cell and developmental biology

Avec: Laleh Pezhman , Abd Tahrani , Myriam Chimen

Changes in Circadian Rhythms Dysregulate Inflammation in Ageing: Focus on Leukocyte Trafficking.

Frontiers in immunology

Avec: Poppy Nathan , Julie Elizabeth Gibbs , G Ed Rainger , Myriam Chimen

Galectin-9: A novel promoter of atherosclerosis progression.

Atherosclerosis

Avec: Franziska Krautter , Mohammed T Hussain , Zhaogong Zhi , Danielle R Lezama , Julia E Manning , Emily Brown , Noemi Marigliano , Federica Raucci , Carlota Recio , Myriam Chimen , Francesco Maione , Alok Tiwari , Helen M McGettrick , Dianne Cooper , Edward A Fisher , Asif J Iqbal

Development of ISB 1442, a CD38 and CD47 bispecific biparatopic antibody innate cell modulator for the treatment of multiple myeloma.

Nature communications

Avec: C Grandclément , C Estoppey , E Dheilly , M Panagopoulou , T Monney , C Dreyfus , J Loyau , V Labanca , A Drake , S De Angelis , A Rubod , J Frei , L N Caro , S Blein , E Martini , M Chimen , T Matthes , Z Kaya , C M Edwards , J R Edwards , E Menoret , C Kervoelen , C Pellat-Deceunynck , P Moreau , M L Mbow , A Srivastava , M R Dyson , E A Zhukovsky , M Perro , S Sammicheli

ISB 2001 trispecific T cell engager shows strong tumor cytotoxicity and overcomes immune escape mechanisms of multiple myeloma cells.

Nature cancer

Avec: Laura Carretero-Iglesia , Olivia J Hall , Jérémy Berret , Daniela Pais , Carole Estoppey , Myriam Chimen , Thierry Monney , Jeremy Loyau , Cyrille Dreyfus , Julie Macoin , Cynthia Perez , Vinu Menon , Isabelle Gruber , Amélie Laurendon , Lydia N Caro , Girish S Gudi , Tomomi Matsuura , Piet H van der Graaf , Stanislas Blein , M Lamine Mbow , Rebecca Croasdale-Wood , Ankita Srivastava , Michael R Dyson , Thomas Matthes , Zeynep Kaya , Claire M Edwards , James R Edwards , Sophie Maiga , Catherine Pellat-Deceunynck , Cyrille Touzeau , Philippe Moreau , Cyril Konto , Adam Drake , Eugene A Zhukovsky , Mario Perro , Maria Pihlgren

Réseau de co-auteurs

Myriam Chimen 14 collaborations

Asif J Iqbal 7 collaborations

Helen M McGettrick 6 collaborations

G Ed Rainger 5 collaborations

Sophie J Hopkin 4 collaborations

Laleh Pezhman 4 collaborations

Franziska Krautter 3 collaborations

James R Edwards 3 collaborations

Jenefa Begum 3 collaborations

Jonathan W Lewis 2 collaborations

Carole Estoppey 2 collaborations

Amélie Laurendon 2 collaborations

Thierry Monney 2 collaborations

Adam Drake 2 collaborations

Laura Carretero-Iglesia 2 collaborations

Julie Macoin 2 collaborations

Jérémy Berret 2 collaborations

Maria Pihlgren 2 collaborations

Girish S Gudi 2 collaborations

Vinu Menon 2 collaborations

Ankita Srivastava 2 collaborations

Stanislas Blein 2 collaborations

M Lamine Mbow 2 collaborations

Thomas Matthes 2 collaborations

Zeynep Kaya 2 collaborations

Claire M Edwards 2 collaborations

Catherine Pellat-Deceunynck 2 collaborations

Philippe Moreau 2 collaborations

Mario Perro 2 collaborations

Dean Kavanagh 2 collaborations

Carlota Recio 2 collaborations

Mohammed T Hussain 2 collaborations

Danielle R Lezama 2 collaborations

Francesco Maione 2 collaborations

Mussarat Wahid 2 collaborations

Amy J Naylor 2 collaborations

Poppy Nathan 2 collaborations

Julia E Manning 2 collaborations

S Hopkin 1 collaboration

J M Lord 1 collaboration

Albertus Viljoen 1 collaboration

Alain Vercellone 1 collaboration

Gérald Gaibelet 1 collaboration

Serge Mazères 1 collaboration

Jérôme Nigou 1 collaboration

Yves F Dufrêne 1 collaboration

Blandine Pouleau 1 collaboration

Perrine Suere 1 collaboration

Emilie Nallet 1 collaboration

Daniela Pais Ferreira 1 collaboration

Marie-Agnès Doucey 1 collaboration

Venkatesha Udupa 1 collaboration

Abhishek Maiti 1 collaboration

Gautam Borthakur 1 collaboration

Emmanuelle Menoret 1 collaboration

Charlotte Kervoëlen 1 collaboration

Eugene Zhukovsky 1 collaboration

Aigli Evryviadou 1 collaboration

Clare L Box 1 collaboration

Matthew J Harrison 1 collaboration

Jon Hazeldine 1 collaboration

Lea H Dib 1 collaboration

Sahithi J Kuravi 1 collaboration

Holly Payne 1 collaboration

Joshua M J Price 1 collaboration

Sian Lax 1 collaboration

Neena Kalia 1 collaboration

Alex Brill 1 collaboration

Steve G Thomas 1 collaboration

Antonio Belli 1 collaboration

Nicholas Crombie 1 collaboration

Rachel A Adams 1 collaboration

Shelley-Ann Evans 1 collaboration

Hans Deckmyn 1 collaboration

Janet M Lord 1 collaboration

Paul Harrison 1 collaboration

Steve P Watson 1 collaboration

Gerard B Nash 1 collaboration

Kathryn Frost 1 collaboration

Georgiana Neag 1 collaboration

Melissa Finlay 1 collaboration

Ellie H Northall 1 collaboration

Oladimeji Abudu 1 collaboration

Edward T Davis 1 collaboration

Emily Powell 1 collaboration

Charlotte Palmer 1 collaboration

Jinsen Lu 1 collaboration

Ansar Mahmood 1 collaboration

Simon W Jones 1 collaboration

Lauren M Quinn 1 collaboration

Silke Heising 1 collaboration

Daniela Nasteska 1 collaboration

David J Hodson 1 collaboration

Chloe Fenton 1 collaboration

Claire Martin 1 collaboration

Rachel Jones 1 collaboration

Adam Croft 1 collaboration

Joana Campos 1 collaboration

Angela E Taylor 1 collaboration

Mark Cooper 1 collaboration

Gareth G Lavery 1 collaboration

Karim Raza 1 collaboration

Rowan S Hardy 1 collaboration

Abd Tahrani 1 collaboration

Julie Elizabeth Gibbs 1 collaboration

Zhaogong Zhi 1 collaboration

Emily Brown 1 collaboration

Noemi Marigliano 1 collaboration

Federica Raucci 1 collaboration

Alok Tiwari 1 collaboration

Dianne Cooper 1 collaboration

Edward A Fisher 1 collaboration

C Grandclément 1 collaboration

C Estoppey 1 collaboration

E Dheilly 1 collaboration

M Panagopoulou 1 collaboration

T Monney 1 collaboration

C Dreyfus 1 collaboration

J Loyau 1 collaboration

V Labanca 1 collaboration

A Drake 1 collaboration

S De Angelis 1 collaboration

A Rubod 1 collaboration

J Frei 1 collaboration

L N Caro 1 collaboration

S Blein 1 collaboration

E Martini 1 collaboration

T Matthes 1 collaboration

Z Kaya 1 collaboration

C M Edwards 1 collaboration

J R Edwards 1 collaboration

E Menoret 1 collaboration

C Kervoelen 1 collaboration

C Pellat-Deceunynck 1 collaboration

P Moreau 1 collaboration

M L Mbow 1 collaboration

A Srivastava 1 collaboration

M R Dyson 1 collaboration

E A Zhukovsky 1 collaboration

M Perro 1 collaboration

S Sammicheli 1 collaboration

Olivia J Hall 1 collaboration

Daniela Pais 1 collaboration

Jeremy Loyau 1 collaboration

Cyrille Dreyfus 1 collaboration

Cynthia Perez 1 collaboration

Isabelle Gruber 1 collaboration

Lydia N Caro 1 collaboration

Tomomi Matsuura 1 collaboration

Piet H van der Graaf 1 collaboration

Rebecca Croasdale-Wood 1 collaboration

Michael R Dyson 1 collaboration

Sophie Maiga 1 collaboration

Cyrille Touzeau 1 collaboration

Cyril Konto 1 collaboration

Eugene A Zhukovsky 1 collaboration