Long-term intake of the illegal diet pill DNP reduces lifespan in a captive bird model.

2,4-Dinitrophenol / toxicity Animals Birds Diet Energy Metabolism Female Finches / metabolism Longevity / drug effects Male Oxidative Phosphorylation / drug effects Oxygen Consumption Uncoupling Agents / toxicity
2,4-Dinitrophenol Longevity Mitochondrial uncoupling Oxidative stress Survival Toxicity

Journal

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
ISSN: 1532-0456
Titre abrégé: Comp Biochem Physiol C Toxicol Pharmacol
Pays: United States
ID NLM: 100959500

Informations de publication

Date de publication:
Apr 2021
Historique:
received: 12 10 2020
revised: 17 11 2020
accepted: 24 11 2020
pubmed: 6 12 2020
medline: 23 7 2021
entrez: 5 12 2020
Statut: ppublish

Résumé

2,4-Dinitrophenol (DNP), a molecule uncoupling mitochondrial oxidative phosphorylation from oxygen consumption, is illegally used by humans as a diet pill, but is nonetheless investigated as a potential human medicine against 'metabesity'. Due to its proven acute toxicity and the scarceness of long-term studies on DNP administration in vertebrates, we determined the impact of a long-term DNP treatment (~4 mg.kg

Identifiants

DOI: 10.1016/j.cbpc.2020.108944 PMID: 33278594
pubmed: 33278594
pii: S1532-0456(20)30244-1
doi: 10.1016/j.cbpc.2020.108944
pii:
doi:

Substances chimiques

Uncoupling Agents 0
2,4-Dinitrophenol Q13SKS21MN

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

108944

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Antoine Stier (A)

Department of Biology, University of Turku, Turku, Finland; Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, UK. Electronic address: amstie@utu.fi.

Pierre Bize (P)

School of Biological Sciences, University of Aberdeen, Aberdeen, UK.

Sylvie Massemin (S)

Université de Strasbourg, CNRS, IPHC UMR 7178, F-67000 Strasbourg, France.

François Criscuolo (F)

Université de Strasbourg, CNRS, IPHC UMR 7178, F-67000 Strasbourg, France.

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Composés nitrés › Nitrophénols › Dinitrophénols › 2,4-Dinitro-phénol › Long-term intake of the illegal diet pill DNP...
questionsmedicales.fr › Eucaryotes › Animaux › Long-term intake of the illegal diet pill DNP...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Oiseaux › Long-term intake of the illegal diet pill DNP...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Long-term intake of the illegal diet pill DNP...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Long-term intake of the illegal diet pill DNP...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Oiseaux › Passeriformes › Oiseaux chanteurs › Fringillidae › Long-term intake of the illegal diet pill DNP...
questionsmedicales.fr › Phénomènes physiologiques › Longévité › Long-term intake of the illegal diet pill DNP...
questionsmedicales.fr › Métabolisme › Phosphorylation › Phosphorylation oxydative › Long-term intake of the illegal diet pill DNP...
questionsmedicales.fr › Métabolisme › Consommation d'oxygène › Long-term intake of the illegal diet pill DNP...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Agents découplants › Long-term intake of the illegal diet pill DNP...