2',4'-BNA/LNA with 9-(2-Aminoethoxy)-1,3-diaza-2-oxophenoxazine Efficiently Forms Duplexes and Has Enhanced Enzymatic Resistance*.
bridged nucleic acids
enzyme resistance
nucleobases
pi interactions
synthesis design
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
01 Feb 2021
01 Feb 2021
Historique:
received:
31
08
2020
pubmed:
7
12
2020
medline:
10
3
2021
entrez:
6
12
2020
Statut:
ppublish
Résumé
Artificial nucleic acids are widely used in various technologies, such as nucleic acid therapeutics and DNA nanotechnologies requiring excellent duplex-forming abilities and enhanced nuclease resistance. 2'-O,4'-C-Methylene-bridged nucleic acid/locked nucleic acid (2',4'-BNA/LNA) with 1,3-diaza-2-oxophenoxazine (BNAP (B
Identifiants
pubmed: 33280173
doi: 10.1002/chem.202003982
pmc: PMC7898338
doi:
Substances chimiques
1,3-diaza-2-oxophenoxazine
0
Bridged-Ring Compounds
0
Nucleic Acids
0
Oligonucleotides
0
Oxazines
0
locked nucleic acid
0
RNA
63231-63-0
Exonucleases
EC 3.1.-
spleen exonuclease
EC 3.1.16.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2427-2438Subventions
Organisme : Japan Science and Technology Agency
ID : Core Research for Evolutional Science and Technology
Organisme : Japan Agency for Medical Research and Development
ID : Platform Project for Supporting Drug Discovery and Life Science Research
Organisme : Japan Agency for Medical Research and Development
ID : JP18am0301004
Organisme : Japan Society for the Promotion of Science
ID : 15K08024
Organisme : Japan Society for the Promotion of Science
ID : 20K05706
Informations de copyright
© 2020 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.
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