Novel plasma biomarkers improve discrimination of metabolic health independent of weight.
Aged
Biomarkers
/ blood
Body Mass Index
Body Weight
/ physiology
Female
Humans
Insulin Resistance
/ physiology
Lipoproteins
/ blood
Lipoproteins, HDL
/ blood
Magnetic Resonance Spectroscopy
Male
Metabolomics
Middle Aged
Myocardial Infarction
/ blood
Proportional Hazards Models
Risk Factors
Tandem Mass Spectrometry
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
07 12 2020
07 12 2020
Historique:
received:
15
04
2020
accepted:
18
11
2020
entrez:
8
12
2020
pubmed:
9
12
2020
medline:
18
5
2021
Statut:
epublish
Résumé
We sought to determine if novel plasma biomarkers improve traditionally defined metabolic health (MH) in predicting risk of cardiovascular disease (CVD) events irrespective of weight. Poor MH was defined in CATHGEN biorepository participants (n > 9300), a follow-up cohort (> 5600 days) comprising participants undergoing evaluation for possible ischemic heart disease. Lipoprotein subparticles, lipoprotein-insulin resistance (LP-IR), and GlycA were measured using NMR spectroscopy (n = 8385), while acylcarnitines and amino acids were measured using flow-injection, tandem mass spectrometry (n = 3592). Multivariable Cox proportional hazards models determined association of poor MH and plasma biomarkers with time-to-all-cause mortality or incident myocardial infarction. Low-density lipoprotein particle size and high-density lipoprotein, small and medium particle size (HMSP), GlycA, LP-IR, short-chain dicarboxylacylcarnitines (SCDA), and branched-chain amino acid plasma biomarkers were independently associated with CVD events after adjustment for traditionally defined MH in the overall cohort (p = 3.3 × 10
Identifiants
pubmed: 33288813
doi: 10.1038/s41598-020-78478-w
pii: 10.1038/s41598-020-78478-w
pmc: PMC7721699
doi:
Substances chimiques
Biomarkers
0
Lipoproteins
0
Lipoproteins, HDL
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
21365Subventions
Organisme : NIH HHS
ID : R01-HL127009
Pays : United States
Organisme : American Heart Association-American Stroke Association
ID : 17SFRN33670990
Pays : United States
Organisme : NHLBI NIH HHS
ID : 5P01-HL036587
Pays : United States
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