White matter integrity and structural brain network topology in cerebral small vessel disease: The Hamburg city health study.
cerebral small vessel disease
diffusion weighted imaging
peak width of skeletonized mean diffusivity
structural brain networks
topological brain network disturbances
white matter hyperintensities of presumed vascular origin
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
01 04 2021
01 04 2021
Historique:
received:
05
04
2020
revised:
08
11
2020
accepted:
16
11
2020
pubmed:
9
12
2020
medline:
5
1
2022
entrez:
8
12
2020
Statut:
ppublish
Résumé
Cerebral small vessel disease is a common finding in the elderly and associated with various clinical sequelae. Previous studies suggest disturbances in the integration capabilities of structural brain networks as a mediating link between imaging and clinical presentations. To what extent cerebral small vessel disease might interfere with other measures of global network topology is not well understood. Connectomes were reconstructed via diffusion weighted imaging in a sample of 930 participants from a population based epidemiologic study. Linear models were fitted testing for an association of graph-theoretical measures reflecting integration and segregation with both the Peak width of Skeletonized Mean Diffusivity (PSMD) and the load of white matter hyperintensities of presumed vascular origin (WMH). The latter were subdivided in periventricular and deep for an analysis of localisation-dependent correlations of cerebral small vessel disease. The median WMH volume was 0.6 mL (1.4) and the median PSMD 2.18 mm
Identifiants
pubmed: 33289924
doi: 10.1002/hbm.25301
pmc: PMC7927298
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1406-1415Informations de copyright
© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
Références
Front Neurol. 2019 Mar 26;10:238
pubmed: 30972001
Nature. 1998 Jun 4;393(6684):440-2
pubmed: 9623998
Atherosclerosis. 2017 Oct;265:305-311
pubmed: 28673480
Neuroimage. 2015 Jan 1;104:253-65
pubmed: 25312774
Neuroimage. 2011 Jan 1;54(1):161-9
pubmed: 20728543
J Alzheimers Dis. 2012;32(3):667-76
pubmed: 22850313
Neuroimage. 2006 Jul 15;31(4):1487-505
pubmed: 16624579
PLoS One. 2015 Apr 02;10(3):e0121945
pubmed: 25835001
Neuroimage. 2019 Jul 1;194:68-81
pubmed: 30844506
Magn Reson Med. 2016 Nov;76(5):1574-1581
pubmed: 26745823
Lancet Neurol. 2013 Aug;12(8):822-38
pubmed: 23867200
Sci Rep. 2016 Feb 25;6:22057
pubmed: 26912196
Neurology. 2016 Mar 22;86(12):1112-9
pubmed: 26888983
Front Aging Neurosci. 2016 Dec 15;8:292
pubmed: 28018208
Neuroimage. 2016 Nov 15;142:394-406
pubmed: 27523449
Neuroinformatics. 2004;2(2):145-62
pubmed: 15319512
Sci Rep. 2020 Jun 8;10(1):9210
pubmed: 32514044
Eur Neuropsychopharmacol. 2015 May;25(5):733-48
pubmed: 24726580
Ann Neurol. 2000 Feb;47(2):145-51
pubmed: 10665484
Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8577-82
pubmed: 16723398
Eur J Epidemiol. 2020 Feb;35(2):169-181
pubmed: 31705407
Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11747-52
pubmed: 19564605
Neuroimage. 2019 Nov 15;202:116137
pubmed: 31473352
Neuroimage. 2012 Sep;62(3):1924-38
pubmed: 22705374
Neuroimage. 2006 Jul 1;31(3):968-80
pubmed: 16530430
Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Jun;71(6 Pt 2):065103
pubmed: 16089800
Neuroimage. 2010 Sep;52(3):1059-69
pubmed: 19819337
Stroke. 2005 Jan;36(1):50-5
pubmed: 15576652
Lancet Neurol. 2010 Jul;9(7):689-701
pubmed: 20610345
Alzheimers Dement. 2018 Jun;14(6):764-774
pubmed: 29406155
Neuroimage. 2018 Apr 15;170:174-181
pubmed: 28315460
Brain. 2015 Jan;138(Pt 1):179-88
pubmed: 25367025
IEEE Trans Med Imaging. 2010 Jun;29(6):1310-20
pubmed: 20378467
J Neurosci. 2009 Jun 10;29(23):7619-24
pubmed: 19515930
Med Image Anal. 2008 Feb;12(1):26-41
pubmed: 17659998
PLoS Comput Biol. 2009 May;5(5):e1000395
pubmed: 19492086
Cereb Cortex. 2011 Jun;21(6):1254-72
pubmed: 21045004
Neurosci Biobehav Rev. 2018 Jul;90:164-173
pubmed: 29656031
Neuroimage. 2016 Jan 15;125:903-919
pubmed: 26520775
Hum Brain Mapp. 2016 Jan;37(1):300-10
pubmed: 26466741
Nat Rev Neurol. 2018 Jul;14(7):387-398
pubmed: 29802354
Nat Rev Neurosci. 2014 Oct;15(10):683-95
pubmed: 25186238
Neuroimage. 2016 Nov 1;141:191-205
pubmed: 27402600
J Affect Disord. 2017 Oct 1;220:8-14
pubmed: 28575716
Neuroimage. 2016 Jan 15;125:1063-1078
pubmed: 26481672
Front Neurol. 2019 Feb 13;10:81
pubmed: 30814973
Hum Brain Mapp. 2021 Apr 1;42(5):1406-1415
pubmed: 33289924
Neurology. 2014 Jul 22;83(4):304-11
pubmed: 24951477
Neurol Neuroimmunol Neuroinflamm. 2017 Jul 27;4(5):e375
pubmed: 28804744
Cereb Cortex. 1994 Jul-Aug;4(4):344-60
pubmed: 7950308
Phys Rev Lett. 2001 Nov 5;87(19):198701
pubmed: 11690461
Biol Psychiatry. 2006 Dec 15;60(12):1304-5
pubmed: 17157096
Ann Neurol. 2016 Oct;80(4):581-92
pubmed: 27518166