Small-Molecule Modulation of PPARs for the Treatment of Prevalent Vascular Retinal Diseases.
age-related macular degeneration
diabetic retinopathy
drug discovery
peroxisome proliferator-activated receptor
retinopathy of prematurity
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
04 Dec 2020
04 Dec 2020
Historique:
received:
20
10
2020
revised:
29
11
2020
accepted:
02
12
2020
entrez:
9
12
2020
pubmed:
10
12
2020
medline:
9
3
2021
Statut:
epublish
Résumé
Vascular-related retinal diseases dramatically impact quality of life and create a substantial burden on the healthcare system. Age-related macular degeneration, diabetic retinopathy, and retinopathy of prematurity are leading causes of irreversible blindness. In recent years, the scientific community has made great progress in understanding the pathology of these diseases and recent discoveries have identified promising new treatment strategies. Specifically, compelling biochemical and clinical evidence is arising that small-molecule modulation of peroxisome proliferator-activated receptors (PPARs) represents a promising approach to simultaneously address many of the pathological drivers of these vascular-related retinal diseases. This has excited academic and pharmaceutical researchers towards developing new and potent PPAR ligands. This review highlights recent developments in PPAR ligand discovery and discusses the downstream effects of targeting PPARs as a therapeutic approach to treating retinal vascular diseases.
Identifiants
pubmed: 33291567
pii: ijms21239251
doi: 10.3390/ijms21239251
pmc: PMC7730325
pii:
doi:
Substances chimiques
Biomarkers
0
Ligands
0
Peroxisome Proliferator-Activated Receptors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NEI NIH HHS
ID : R21EY028279
Pays : United States
Organisme : NEI NIH HHS
ID : R01EY030472
Pays : United States
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