Additive Effects of Omega-3 Fatty Acids and Thiazolidinediones in Mice Fed a High-Fat Diet: Triacylglycerol/Fatty Acid Cycling in Adipose Tissue.
Adipocytes
/ drug effects
Adipose Tissue, White
/ metabolism
Animals
Diet, High-Fat
Fatty Acids
/ metabolism
Fatty Acids, Omega-3
/ administration & dosage
Hypoglycemic Agents
/ pharmacology
Lipid Metabolism
/ drug effects
Lipogenesis
/ drug effects
Male
Mice
Mice, Inbred C57BL
Mice, Obese
Obesity
/ drug therapy
Pioglitazone
/ pharmacology
Thiazolidinediones
/ administration & dosage
Triglycerides
/ metabolism
adipocytes
glucose homeostasis
insulin
lipogenesis
obesity
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
04 Dec 2020
04 Dec 2020
Historique:
received:
06
11
2020
revised:
30
11
2020
accepted:
02
12
2020
entrez:
9
12
2020
pubmed:
10
12
2020
medline:
10
4
2021
Statut:
epublish
Résumé
Long-chain n-3 polyunsaturated fatty acids (Omega-3) and anti-diabetic drugs thiazolidinediones (TZDs) exhibit additive effects in counteraction of dietary obesity and associated metabolic dysfunctions in mice. The underlying mechanisms need to be clarified. Here, we aimed to learn whether the futile cycle based on the hydrolysis of triacylglycerol and re-esterification of fatty acids (TAG/FA cycling) in white adipose tissue (WAT) could be involved. We compared Omega-3 (30 mg/g diet) and two different TZDs-pioglitazone (50 mg/g diet) and a second-generation TZD, MSDC-0602K (330 mg/g diet)-regarding their effects in C57BL/6N mice fed an obesogenic high-fat (HF) diet for 8 weeks. The diet was supplemented or not by the tested compound alone or with the two TZDs combined individually with Omega-3. Activity of TAG/FA cycle in WAT was suppressed by the obesogenic HF diet. Additive effects in partial rescue of TAG/FA cycling in WAT were observed with both combined interventions, with a stronger effect of Omega-3 and MSDC-0602K. Our results (i) supported the role of TAG/FA cycling in WAT in the beneficial additive effects of Omega-3 and TZDs on metabolism of diet-induced obese mice, and (ii) showed differential modulation of WAT gene expression and metabolism by the two TZDs, depending also on Omega-3.
Identifiants
pubmed: 33291653
pii: nu12123737
doi: 10.3390/nu12123737
pmc: PMC7761951
pii:
doi:
Substances chimiques
Fatty Acids
0
Fatty Acids, Omega-3
0
Hypoglycemic Agents
0
Thiazolidinediones
0
Triglycerides
0
Pioglitazone
X4OV71U42S
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Grantová Agentura České Republiky
ID : 19-02411S
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