Altered network architecture of functional brain communities in chronic nociplastic pain.
Chronic pain
Community structure
Fibromyalgia
Graph theory
Normalized mutual information
Resting state fMRI
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
01 02 2021
01 02 2021
Historique:
received:
16
12
2019
revised:
17
10
2020
accepted:
20
10
2020
pubmed:
10
12
2020
medline:
2
3
2021
entrez:
9
12
2020
Statut:
ppublish
Résumé
Neuroimaging has enhanced our understanding of the neural correlates of pain. Yet, how neural circuits interact and contribute to persistent pain remain largely unknown. Here, we investigate the mesoscale organization of the brain through intrinsic functional communities generated from resting state functional MRI data from two independent datasets, a discovery cohort of 43 Fibromyalgia (FM) patients and 20 healthy controls (HC) as well as a replication sample of 34 FM patients and 21 HC. Using normalized mutual information, we found that the global network architecture in chronic pain patients is less stable (more variable). Subsequent analyses of node community assignment revealed the composition of the communities differed between FM and HC. Furthermore, differences in network organization were associated with the changes in the composition of communities between patients with varying levels of clinical pain. Together, this work demonstrates that intrinsic network communities differ substantially between patients with FM and controls. These differences may represent a novel aspect of the pathophysiology of chronic nociplastic pain.
Identifiants
pubmed: 33293261
pii: S1053-8119(20)30989-7
doi: 10.1016/j.neuroimage.2020.117504
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
117504Subventions
Organisme : NINDS NIH HHS
ID : F99 NS108556
Pays : United States
Informations de copyright
Copyright © 2020. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of Competing Interest D.J.C has received consultant fees, speaking fees, and/or honoraria from Aptinyx, Daiichi Sankyo, Intec Pharma, Eli Lilly, Pfizer, Nix Patterson LLP, Samumed, Theravance, Tonix, Williams, & Connolly LLP and Zynerba. D.J.C has also received research support from Aptinyx and Pfizer. S.E.H. has received Grants and personal fees from Pfizer, Aptinyx, Arbor Medical Innovations; grants from Cerephex, Lilly, and Forest. R.E.H has consulted for Pfizer, Aptinyx Inc. He has received grant funding from Pfizer, Aptinyx and Cerephex. T.E.L., C.M.K., A.S., E.I., I.M., S.E.H., G.A.M., D.J.C., and R.E.H., have all received funding from the National Institutes of Health. The remaining authors declare no competing interests.