Non-invasive biomarkers for monitoring the immunotherapeutic response to cancer.
Cancer metabolism
Imaging biomarkers
Immunotherapy
T cells
Tumor microenvironment
Journal
Journal of translational medicine
ISSN: 1479-5876
Titre abrégé: J Transl Med
Pays: England
ID NLM: 101190741
Informations de publication
Date de publication:
09 12 2020
09 12 2020
Historique:
received:
13
07
2020
accepted:
01
12
2020
entrez:
10
12
2020
pubmed:
11
12
2020
medline:
15
5
2021
Statut:
epublish
Résumé
Immunotherapy is an efficient way to cure cancer by modulating the patient's immune response. However, the immunotherapy response is heterogeneous and varies between individual patients and cancer subtypes, reinforcing the need for early benefit predictors. Evaluating the infiltration of immune cells in the tumor and changes in cell-intrinsic tumor characteristics provide potential response markers to treatment. However, this approach requires invasive sampling and may not be suitable for real-time monitoring of treatment response. The recent emergence of quantitative imaging biomarkers provides promising opportunities. In vivo imaging technologies that interrogate T cell responses, metabolic activities, and immune microenvironment could offer a powerful tool to monitor the cancer response to immunotherapy. Advances in imaging techniques to identify tumors' immunological characteristics can help stratify patients who are more likely to respond to immunotherapy. This review discusses the metabolic events that occur during T cell activation and differentiation, anti-cancer immunotherapy-induced T cell responses, focusing on non-invasive imaging techniques to monitor T cell metabolism in the search for novel biomarkers of response to cancer immunotherapy.
Identifiants
pubmed: 33298096
doi: 10.1186/s12967-020-02656-7
pii: 10.1186/s12967-020-02656-7
pmc: PMC7727217
doi:
Substances chimiques
Biomarkers
0
Biomarkers, Tumor
0
Immunologic Factors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
471Subventions
Organisme : Sidra Medicine
ID : 5071012001
Pays : International
Organisme : Sidra Medicine
ID : 5011041002
Pays : International
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