Diagnostic Accuracy Study of a Novel Blood-Based Assay for Identification of Tuberculosis in People Living with HIV.
3-gene
Cepheid
Xpert
diagnostics
gene signature
host response
human immunodeficiency virus
nonsputum
rapid tests
tuberculosis
Journal
Journal of clinical microbiology
ISSN: 1098-660X
Titre abrégé: J Clin Microbiol
Pays: United States
ID NLM: 7505564
Informations de publication
Date de publication:
18 02 2021
18 02 2021
Historique:
received:
03
07
2020
accepted:
02
12
2020
pubmed:
11
12
2020
medline:
9
7
2021
entrez:
10
12
2020
Statut:
epublish
Résumé
A nonsputum triage test to rule out tuberculosis (TB) disease is a WHO high-priority diagnostic, and a combinatory score based on a 3-gene host signature has shown promise in discriminating TB from other illnesses. We evaluated the accuracy of an early-prototype cartridge assay ("Xpert MTB Host Response" or Xpert-MTB-HR-Prototype) of this 3-gene signature on biobanked blood samples from people living with HIV (PLHIV) against a comprehensive microbiological reference standard (CMRS) and against Xpert MTB/RIF on the first sputum sample alone. We depict results based on performance targets set by the WHO in comparison with a laboratory-based C-reactive protein (CRP) assay. Of 201 patients included, 67 were culture positive for
Identifiants
pubmed: 33298607
pii: JCM.01643-20
doi: 10.1128/JCM.01643-20
pmc: PMC8106701
pii:
doi:
Substances chimiques
Rifampin
VJT6J7R4TR
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI125197
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI057229
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI109662
Pays : United States
Informations de copyright
Copyright © 2021 Södersten et al.
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