Xpert MTB/XDR: a 10-Color Reflex Assay Suitable for Point-of-Care Settings To Detect Isoniazid, Fluoroquinolone, and Second-Line-Injectable-Drug Resistance Directly from Mycobacterium tuberculosis-Positive Sputum.
Diagnostic Tests, Routine
Drug Resistance
Drug Resistance, Bacterial
Fluoroquinolones
/ pharmacology
Humans
Isoniazid
/ pharmacology
Microbial Sensitivity Tests
Mycobacterium tuberculosis
/ genetics
Point-of-Care Systems
Reflex
Rifampin
Sensitivity and Specificity
Sputum
Tuberculosis, Multidrug-Resistant
/ diagnosis
10-color
GeneXpert
Mycobacterium tuberculosis
TB
XDR
drug resistance
rapid diagnostics
Journal
Journal of clinical microbiology
ISSN: 1098-660X
Titre abrégé: J Clin Microbiol
Pays: United States
ID NLM: 7505564
Informations de publication
Date de publication:
18 02 2021
18 02 2021
Historique:
received:
08
09
2020
accepted:
22
11
2020
pubmed:
11
12
2020
medline:
9
7
2021
entrez:
10
12
2020
Statut:
epublish
Résumé
We describe the design, development, analytical performance, and a limited clinical evaluation of the 10-color Xpert MTB/XDR assay (CE-IVD only, not for sale in the United States). This assay is intended as a reflex test to detect resistance to isoniazid (INH), fluoroquinolones (FLQ), ethionamide (ETH), and second-line injectable drugs (SLIDs) in unprocessed sputum samples and concentrated sputum sediments which are positive for
Identifiants
pubmed: 33298611
pii: JCM.02314-20
doi: 10.1128/JCM.02314-20
pmc: PMC8106700
pii:
doi:
Substances chimiques
Fluoroquinolones
0
Isoniazid
V83O1VOZ8L
Rifampin
VJT6J7R4TR
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI111397
Pays : United States
Informations de copyright
Copyright © 2021 American Society for Microbiology.
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