Endothelial S1P

Animals Blood-Brain Barrier / drug effects Cerebral Arteries / drug effects Cerebrovascular Circulation Disease Models, Animal Endothelial Cells / metabolism Female Infarction, Middle Cerebral Artery / metabolism Ischemic Attack, Transient / metabolism Ischemic Stroke / metabolism Lysophospholipids / metabolism Male Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout Microcirculation Neuroprotective Agents / pharmacology Signal Transduction Sphingosine / analogs & derivatives Sphingosine-1-Phosphate Receptors / agonists Vascular Patency
blood-brain barrier collateral circulation endothelium fingolimod hydrochloride neuroprotective agents stroke

Journal

Circulation research
ISSN: 1524-4571
Titre abrégé: Circ Res
Pays: United States
ID NLM: 0047103

Informations de publication

Date de publication:
05 02 2021
Historique:
pubmed: 11 12 2020
medline: 27 7 2021
entrez: 10 12 2020
Statut: ppublish

Résumé

Cerebrovascular function is critical for brain health, and endogenous vascular protective pathways may provide therapeutic targets for neurological disorders. S1P (Sphingosine 1-phosphate) signaling coordinates vascular functions in other organs, and S1P To address roles and mechanisms of engagement of endothelial cell S1P Using spatial modulation of S1P provision and signaling, we demonstrate a critical vascular protective role for endothelial S1P This study provides genetic evidence to support a pivotal role for the endothelium in maintaining perfusion and microvascular patency in the ischemic penumbra that is coordinated by S1P signaling and can be harnessed for neuroprotection with blood-brain barrier-penetrating S1P

Identifiants

DOI: 10.1161/CIRCRESAHA.120.316711 PMID: 33301355 PMC: PMC7874503
pubmed: 33301355
doi: 10.1161/CIRCRESAHA.120.316711
pmc: PMC7874503
mid: NIHMS1653038
doi:

Substances chimiques

Lysophospholipids 0
Neuroprotective Agents 0
S1pr1 protein, mouse 0
Sphingosine-1-Phosphate Receptors 0
sphingosine 1-phosphate 26993-30-6
Sphingosine NGZ37HRE42

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Video-Audio Media

Langues

eng

Sous-ensembles de citation

IM

Pagination

363-382

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS034179
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS114561
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL135821
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA DK056014
Pays : United States

Commentaires et corrections

Type : CommentIn

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Auteurs

Anja Nitzsche (A)

Université de Paris, Paris Cardiovascular Research Centre, INSERM U970, France (A.N., M.P., A.B., T.M., G.A., V.B., L.C., A.C., H.N., P.-L.T., A.E., B.T., E.C.).

Marine Poittevin (M)

Université de Paris, Paris Cardiovascular Research Centre, INSERM U970, France (A.N., M.P., A.B., T.M., G.A., V.B., L.C., A.C., H.N., P.-L.T., A.E., B.T., E.C.).
Institut des Vaisseaux et du Sang, Hôpital Lariboisière, France (M.P., P.-L.L.).

Ammar Benarab (A)

Université de Paris, Paris Cardiovascular Research Centre, INSERM U970, France (A.N., M.P., A.B., T.M., G.A., V.B., L.C., A.C., H.N., P.-L.T., A.E., B.T., E.C.).

Philippe Bonnin (P)

Université de Paris, INSERM U965 and Physiologie Clinique - Explorations-Fonctionnelles, AP-HP, Hôpital Lariboisière, France (P.B., N.K.).

Giuseppe Faraco (G)

Feil Family Brain and Mind Research Institute (G.F., L.G.-B., C.I.), Weill Cornell Medical College, Cornell University, New York.

Hiroki Uchida (H)

Center for Vascular Biology (H.U., T.S.), Weill Cornell Medical College, Cornell University, New York.

Julie Favre (J)

MITOVASC Institute, CARFI Facility, CNRS UMR 6015, INSERM U1083, Angers University, France (J.F., M.C.L.G., D.H.).

Lidia Garcia-Bonilla (L)

Feil Family Brain and Mind Research Institute (G.F., L.G.-B., C.I.), Weill Cornell Medical College, Cornell University, New York.

Manuela C L Garcia (MCL)

MITOVASC Institute, CARFI Facility, CNRS UMR 6015, INSERM U1083, Angers University, France (J.F., M.C.L.G., D.H.).

Pierre-Louis Léger (PL)

Institut des Vaisseaux et du Sang, Hôpital Lariboisière, France (M.P., P.-L.L.).
INSERM U1141, Hôpital Robert Debré (P.-L.L., C.C.-M.).

Patrice Thérond (P)

Assistance Publique-Hôpitaux de Paris (AP-HP), Service de Biochimie, Hôpital de Bicêtre, Le Kremlin Bicêtre, France (P.T.).
Université Paris-Sud, France (P.T.).
UFR de Pharmacie, EA 4529, Châtenay-Malabry, France (P.T.).

Thomas Mathivet (T)

Université de Paris, Paris Cardiovascular Research Centre, INSERM U970, France (A.N., M.P., A.B., T.M., G.A., V.B., L.C., A.C., H.N., P.-L.T., A.E., B.T., E.C.).

Gwennhael Autret (G)

Université de Paris, Paris Cardiovascular Research Centre, INSERM U970, France (A.N., M.P., A.B., T.M., G.A., V.B., L.C., A.C., H.N., P.-L.T., A.E., B.T., E.C.).

Véronique Baudrie (V)

Université de Paris, Paris Cardiovascular Research Centre, INSERM U970, France (A.N., M.P., A.B., T.M., G.A., V.B., L.C., A.C., H.N., P.-L.T., A.E., B.T., E.C.).

Ludovic Couty (L)

Université de Paris, Paris Cardiovascular Research Centre, INSERM U970, France (A.N., M.P., A.B., T.M., G.A., V.B., L.C., A.C., H.N., P.-L.T., A.E., B.T., E.C.).

Mari Kono (M)

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Institutes of Health, Bethesda, MD, USA (M.K., R.L.P.).

Aline Chevallier (A)

Hira Niazi (H)

Université de Paris, Paris Cardiovascular Research Centre, INSERM U970, France (A.N., M.P., A.B., T.M., G.A., V.B., L.C., A.C., H.N., P.-L.T., A.E., B.T., E.C.).

Pierre-Louis Tharaux (PL)

Université de Paris, Paris Cardiovascular Research Centre, INSERM U970, France (A.N., M.P., A.B., T.M., G.A., V.B., L.C., A.C., H.N., P.-L.T., A.E., B.T., E.C.).

Jerold Chun (J)

Neuroscience Drug Discovery, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA (J.C.).

Susan R Schwab (SR)

Skirball Institute of Biomolecular Medicine, New York University School of Medicine, NY (S.R.S.).

Anne Eichmann (A)

Université de Paris, Paris Cardiovascular Research Centre, INSERM U970, France (A.N., M.P., A.B., T.M., G.A., V.B., L.C., A.C., H.N., P.-L.T., A.E., B.T., E.C.).

Bertrand Tavitian (B)

Université de Paris, Paris Cardiovascular Research Centre, INSERM U970, France (A.N., M.P., A.B., T.M., G.A., V.B., L.C., A.C., H.N., P.-L.T., A.E., B.T., E.C.).

Richard L Proia (RL)

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Institutes of Health, Bethesda, MD, USA (M.K., R.L.P.).

Christiane Charriaut-Marlangue (C)

INSERM U1141, Hôpital Robert Debré (P.-L.L., C.C.-M.).

Teresa Sanchez (T)

Center for Vascular Biology (H.U., T.S.), Weill Cornell Medical College, Cornell University, New York.

Nathalie Kubis (N)

Université de Paris, INSERM U965 and Physiologie Clinique - Explorations-Fonctionnelles, AP-HP, Hôpital Lariboisière, France (P.B., N.K.).
Université de Paris, INSERM U1148, Hôpital Bichat, France (N.K.).

Daniel Henrion (D)

MITOVASC Institute, CARFI Facility, CNRS UMR 6015, INSERM U1083, Angers University, France (J.F., M.C.L.G., D.H.).

Costantino Iadecola (C)

Feil Family Brain and Mind Research Institute (G.F., L.G.-B., C.I.), Weill Cornell Medical College, Cornell University, New York.

Timothy Hla (T)

Vascular Biology Program, Boston Children's Hospital, MA (T.H.).

Eric Camerer (E)

Université de Paris, Paris Cardiovascular Research Centre, INSERM U970, France (A.N., M.P., A.B., T.M., G.A., V.B., L.C., A.C., H.N., P.-L.T., A.E., B.T., E.C.).

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Endothelial S1P
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Barrière hémato-encéphalique › Endothelial S1P
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Artères › Artères cérébrales › Endothelial S1P
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Circulation sanguine › Circulation cérébrovasculaire › Endothelial S1P
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Endothelial S1P
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Endothelial S1P
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Infarctus › Infarctus encéphalique › Infarctus cérébral › Infarctus du territoire de l'artère cérébrale moyenne › Endothelial S1P
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Encéphalopathie ischémique › Accident ischémique transitoire › Endothelial S1P
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › Accident vasculaire cérébral ischémique › Endothelial S1P
questionsmedicales.fr › Lipides › Lipides membranaires › Phospholipides › Glycérophosphate › Acides phosphatidiques › Lysophospholipides › Endothelial S1P
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Souris de souche-129 › Endothelial S1P
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Endothelial S1P
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Endothelial S1P
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Circulation sanguine › Microcirculation › Endothelial S1P
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Neuroprotecteurs › Endothelial S1P
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Endothelial S1P
questionsmedicales.fr › Composés chimiques organiques › Amines › Aminoalcools › Sphingosine › Endothelial S1P
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs aux lysophospholipides › Récepteurs aux lysosphingolipides › Récepteurs de la sphingosine-1-phosphate › Endothelial S1P
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Degré de perméabilité vasculaire › Endothelial S1P