A Disinhibitory Circuit for Contextual Modulation in Primary Visual Cortex.
canonical disinhibitory circuit
computational modeling
contextual modulation
figure-ground segregation
inhibitory neurons
pop-out effects
recurrent neural network
saliency
stabilized supralinear network
visual cortex
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
23 12 2020
23 12 2020
Historique:
received:
30
04
2020
revised:
17
10
2020
accepted:
13
11
2020
pubmed:
11
12
2020
medline:
3
2
2021
entrez:
10
12
2020
Statut:
ppublish
Résumé
Context guides perception by influencing stimulus saliency. Accordingly, in visual cortex, responses to a stimulus are modulated by context, the visual scene surrounding the stimulus. Responses are suppressed when stimulus and surround are similar but not when they differ. The underlying mechanisms remain unclear. Here, we use optical recordings, manipulations, and computational modeling to show that disinhibitory circuits consisting of vasoactive intestinal peptide (VIP)-expressing and somatostatin (SOM)-expressing inhibitory neurons modulate responses in mouse visual cortex depending on similarity between stimulus and surround, primarily by modulating recurrent excitation. When stimulus and surround are similar, VIP neurons are inactive, and activity of SOM neurons leads to suppression of excitatory neurons. However, when stimulus and surround differ, VIP neurons are active, inhibiting SOM neurons, which leads to relief of excitatory neurons from suppression. We have identified a canonical cortical disinhibitory circuit that contributes to contextual modulation and may regulate perceptual saliency.
Identifiants
pubmed: 33301712
pii: S0896-6273(20)30891-6
doi: 10.1016/j.neuron.2020.11.013
pmc: PMC7850578
mid: NIHMS1654637
pii:
doi:
Substances chimiques
Vasoactive Intestinal Peptide
37221-79-7
Somatostatin
51110-01-1
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1181-1193.e8Subventions
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NCRR NIH HHS
ID : G20 RR030893
Pays : United States
Organisme : NINDS NIH HHS
ID : U19 NS107613
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.
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