Forkhead Transcription Factors in Health and Disease.

Aging / physiology Animals Evolution, Molecular Forkhead Transcription Factors / chemistry Gene Expression Regulation Genetic Diseases, Inborn / genetics Humans Mice Multigene Family Neoplasms / genetics
Forkhead transcription factors cancer forkhead box factors human diseasen transcription

Journal

Trends in genetics : TIG
ISSN: 0168-9525
Titre abrégé: Trends Genet
Pays: England
ID NLM: 8507085

Informations de publication

Date de publication:
05 2021
Historique:
received: 02 10 2020
revised: 04 11 2020
accepted: 05 11 2020
pubmed: 12 12 2020
medline: 1 9 2021
entrez: 11 12 2020
Statut: ppublish

Résumé

Forkhead box (FOX) proteins belong to an evolutionarily conserved family of transcription factors that has evolved by gene/genome duplication. FOX family members have undergone sequence and regulatory diversification. However, they have retained some degree of functional redundancy, in addition to playing specific roles, both during development and in the adult. Genetic alterations or misregulation of FOX genes underlie human genetic diseases, cancer, and/or aging. In this review, we provide an updated overview of the main characteristics of the members of this family, in terms of breadth of expression, protein domain composition, evolution, and function.

Identifiants

DOI: 10.1016/j.tig.2020.11.003 PMID: 33303287
pubmed: 33303287
pii: S0168-9525(20)30308-5
doi: 10.1016/j.tig.2020.11.003
pii:
doi:

Substances chimiques

Forkhead Transcription Factors 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

460-475

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Laetitia Herman (L)

Université de Paris, F-75006, Paris, France; Université de Paris, CNRS, Institut Jacques Monod, F-75006, Paris, France.

Anne-Laure Todeschini (AL)

Université de Paris, F-75006, Paris, France; Université de Paris, CNRS, Institut Jacques Monod, F-75006, Paris, France.

Reiner A Veitia (RA)

Université de Paris, F-75006, Paris, France; Université de Paris, CNRS, Institut Jacques Monod, F-75006, Paris, France; Université Paris-Saclay, Institut de Biologie F. Jacob, Commissariat à l'Energie Atomique, Fontenay aux Roses, France. Electronic address: reiner.veitia@ijm.fr.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Forkhead Transcription Factors in Health and Disease.
questionsmedicales.fr › Eucaryotes › Animaux › Forkhead Transcription Factors in Health and Disease.
questionsmedicales.fr › Phénomènes biologiques › Évolution biologique › Évolution moléculaire › Forkhead Transcription Factors in Health and Disease.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif hélice ailée › Facteurs de transcription Forkhead › Forkhead Transcription Factors in Health and Disease.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Forkhead Transcription Factors in Health and Disease.
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Forkhead Transcription Factors in Health and Disease.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Forkhead Transcription Factors in Health and Disease.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Forkhead Transcription Factors in Health and Disease.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Famille multigénique › Forkhead Transcription Factors in Health and Disease.
questionsmedicales.fr › Tumeurs › Forkhead Transcription Factors in Health and Disease.