OXTR rs53576 Variation with Breast and Nipple Pain in Breastfeeding Women.
Journal
Pain management nursing : official journal of the American Society of Pain Management Nurses
ISSN: 1532-8635
Titre abrégé: Pain Manag Nurs
Pays: United States
ID NLM: 100890606
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
09
06
2020
revised:
18
08
2020
accepted:
14
09
2020
pubmed:
12
12
2020
medline:
26
11
2021
entrez:
11
12
2020
Statut:
ppublish
Résumé
Thirty percent of women who seek professional breastfeeding support require assistance with ongoing breast and nipple pain and < 50% of women report resolution of their pain. It is unknown if there is a molecular risk for ongoing breast and nipple pain during breastfeeding. Aim -To evaluate associations among breast and nipple pain sensitivity and candidate pain sensitivity single-nucleotide polymorphisms [SNPs], (COMT rs6269, rs4633, rs4818, rs4680 and OXTR rs2254298, rs53576) in breastfeeding women. Design - A secondary analysis of a pilot randomized controlled trial of a pain self-management intervention conducted over 6 weeks postpartum. Setting and Participants - Sixty women were recruited from two hospital settings after birth. Methods - All participants underwent standardized mechanical somatosensory testing for an assessment of pain sensitivity and provided baseline buccal swabs for genetic analysis. At 1, 2, and 6 weeks postpartum, women self-reported breast and nipple pain severity using a visual analogue scale. Results - Women with the minor allele OXTR rs53576 reported 8.18-fold higher breast and nipple pain severity over time. For every 1-unit increase in Mechanical detection threshold and windup ratio, women reported 16.51-fold and 4.82-fold higher breast and nipple pain severity respectively. Six women with the OXTR rs2254298 minor allele reported allodynia. Conclusion - The presence of OXTR alleles in women with enhanced pain sensitivity suggests a phenotype of genetic risk for ongoing breast and nipple with potential for pain-associated breastfeeding cessation. Somatosensory testing identified women who reported higher breast and nipple pain during the first weeks of breastfeeding.
Sections du résumé
BACKGROUND
Thirty percent of women who seek professional breastfeeding support require assistance with ongoing breast and nipple pain and < 50% of women report resolution of their pain. It is unknown if there is a molecular risk for ongoing breast and nipple pain during breastfeeding. Aim -To evaluate associations among breast and nipple pain sensitivity and candidate pain sensitivity single-nucleotide polymorphisms [SNPs], (COMT rs6269, rs4633, rs4818, rs4680 and OXTR rs2254298, rs53576) in breastfeeding women. Design - A secondary analysis of a pilot randomized controlled trial of a pain self-management intervention conducted over 6 weeks postpartum. Setting and Participants - Sixty women were recruited from two hospital settings after birth. Methods - All participants underwent standardized mechanical somatosensory testing for an assessment of pain sensitivity and provided baseline buccal swabs for genetic analysis. At 1, 2, and 6 weeks postpartum, women self-reported breast and nipple pain severity using a visual analogue scale. Results - Women with the minor allele OXTR rs53576 reported 8.18-fold higher breast and nipple pain severity over time. For every 1-unit increase in Mechanical detection threshold and windup ratio, women reported 16.51-fold and 4.82-fold higher breast and nipple pain severity respectively. Six women with the OXTR rs2254298 minor allele reported allodynia. Conclusion - The presence of OXTR alleles in women with enhanced pain sensitivity suggests a phenotype of genetic risk for ongoing breast and nipple with potential for pain-associated breastfeeding cessation. Somatosensory testing identified women who reported higher breast and nipple pain during the first weeks of breastfeeding.
Identifiants
pubmed: 33303340
pii: S1524-9042(20)30196-X
doi: 10.1016/j.pmn.2020.09.007
pmc: PMC8933061
mid: NIHMS1788065
pii:
doi:
Substances chimiques
OXTR protein, human
0
Receptors, Oxytocin
0
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
369-376Subventions
Organisme : NINR NIH HHS
ID : P20 NR016605
Pays : United States
Informations de copyright
Copyright © 2020 American Society for Pain Management Nursing. Published by Elsevier Inc. All rights reserved.
Références
Pain. 2019 Jan;160(1):45-52
pubmed: 30586070
J Pain. 2005 Mar;6(3):159-67
pubmed: 15772909
Nurs Res. 2019 Mar/Apr;68(2):E1-E10
pubmed: 30829925
JAMA. 2016 Oct 25;316(16):1688-1693
pubmed: 27784102
Biol Res Nurs. 2017 May;19(3):318-328
pubmed: 28205449
Dev Cogn Neurosci. 2014 Jul;9:160-71
pubmed: 24814480
J Pediatr. 2018 Dec;203:197-203.e2
pubmed: 30297289
Lancet. 2016 Jan 30;387(10017):475-90
pubmed: 26869575
Breastfeed Med. 2016 Mar;11(2):46-53
pubmed: 26881962
Breastfeed Med. 2015 Jul-Aug;10(6):290-9
pubmed: 26204124
J Hum Lact. 2012 Nov;28(4):511-21
pubmed: 22689707
Br J Anaesth. 2008 Jul;101(1):17-24
pubmed: 18487245
Am J Obstet Gynecol. 2012 Sep;207(3):184.e1-8
pubmed: 22939719
J Neuroendocrinol. 2018 Jan 11;:
pubmed: 29323764
Neurosci Biobehav Rev. 2015 Aug;55:53-67
pubmed: 25956252
Breastfeed Med. 2018 May;13(4):275-280
pubmed: 29630399
Appl Nurs Res. 2016 Feb;29:237-41
pubmed: 26856520
Res Nurs Health. 2019 Jun;42(3):176-188
pubmed: 30835887
Neurosignals. 2018;26(1):11-21
pubmed: 29402857
Genes Brain Behav. 2018 Sep;17(7):e12464
pubmed: 29412506
Sci Rep. 2017 Sep 14;7(1):11618
pubmed: 28912494
J Adv Nurs. 2019 Jun;75(6):1162-1172
pubmed: 30407654
Eur J Clin Nutr. 2016 Dec;70(12):1420-1427
pubmed: 27460268
Neurochem Int. 2017 Feb;103:57-64
pubmed: 28065792
Soc Cogn Affect Neurosci. 2008 Jun;3(2):128-34
pubmed: 19015103
Neuroscience. 1996 Jan;70(1):227-45
pubmed: 8848127
Int J Environ Res Public Health. 2015 Sep 29;12(10):12247-63
pubmed: 26426034
Breastfeed Med. 2019 Dec;14(10):705-711
pubmed: 31483146
Hum Mol Genet. 2005 Jan 1;14(1):135-43
pubmed: 15537663
Pain. 2013 Sep;154(9):1807-1819
pubmed: 23742795
Eur J Pain. 2006 Jan;10(1):77-88
pubmed: 16291301
MCN Am J Matern Child Nurs. 2019 Mar/Apr;44(2):66-72
pubmed: 30688667
Obstet Gynecol. 2013 Nov;122(5):1047-1055
pubmed: 24104772
Aust Fam Physician. 2015 Mar;44(3):127-32
pubmed: 25770578
J Pediatr. 1948 Dec;33(6):698-704
pubmed: 18101061
Pediatrics. 2013 Mar;131(3):e726-32
pubmed: 23420922
Neurosci Biobehav Rev. 2013 Sep;37(8):1597-610
pubmed: 23792050
Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15118-22
pubmed: 21896752