Variables associated with insulin production in persons with type 2 diabetes treated with multiple daily insulin injections.

Blood Glucose Diabetes Mellitus, Type 2 / diagnosis Glycated Hemoglobin / analysis Humans Hypoglycemic Agents / adverse effects Insulin / adverse effects Insulin Infusion Systems Liraglutide / therapeutic use
C-peptide and proinsulin and related variables Insulin secretion Multiple daily insulin injections Type 2 diabetes mellitus

Journal

Primary care diabetes
ISSN: 1878-0210
Titre abrégé: Prim Care Diabetes
Pays: England
ID NLM: 101463825

Informations de publication

Date de publication:
06 2021
Historique:
received: 15 01 2020
revised: 31 08 2020
accepted: 11 11 2020
pubmed: 12 12 2020
medline: 16 10 2021
entrez: 11 12 2020
Statut: ppublish

Résumé

From the MDI-liraglutide study, we evaluated variables associated with endogenous insulin production in persons with multiple daily insulin injections-treated type 2 diabetes by relating C-peptide, proinsulin and proinsulin/C-peptide ratio at baseline to baseline variables. Lower insulin production was related to longer diabetes duration, shorter abdominal sagittal diameter and more glycaemic variability.

Identifiants

DOI: 10.1016/j.pcd.2020.11.005 PMID: 33303380
pubmed: 33303380
pii: S1751-9918(20)30321-1
doi: 10.1016/j.pcd.2020.11.005
pii:
doi:

Substances chimiques

Blood Glucose 0
Glycated Hemoglobin A 0
Hypoglycemic Agents 0
Insulin 0
Liraglutide 839I73S42A

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

607-613

Informations de copyright

Copyright © 2020 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.

Auteurs

Klara Westman (K)

Department of Medicine, NU-Hospital Group, Trollhättan/Uddevalla, Sweden; Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden. Electronic address: klawe165@student.liu.se.

Henrik Imberg (H)

Statistiska Konsultgruppen, Gothenburg, Sweden; Department of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Gothenburg, Sweden.

Henrik Albrektsson (H)

Statistiska Konsultgruppen, Gothenburg, Sweden.

Irl B Hirsch (IB)

University of Washington School of Medicine, UW Medicine Diabetes Institute, Seattle, WA 98109, United States.

Jaakko Tuomilehto (J)

Public Health Promotion Unit, Finnish Institute for Health and Welfare, P.O. Box 30, 00271 Helsinki, Finland; Department of Public Health, University of Helsinki, 00014 Helsinki, Finland; Saudi Diabetes Research Group, King Abdulaziz University, 21589 Jeddah, Saudi Arabia.

Sofia Dahlqvist (S)

Department of Medicine, NU-Hospital Group, Trollhättan/Uddevalla, Sweden; Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.

Marcus Lind (M)

Department of Medicine, NU-Hospital Group, Trollhättan/Uddevalla, Sweden; Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.

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Classifications MeSH

questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Glycémie › Variables associated with insulin production...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Variables associated with insulin production...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Produits terminaux de glycation avancée › Protéines glyquées › Protéine glycosylée sérique › Hémoglobine glycosylée › Variables associated with insulin production...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Variables associated with insulin production...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › Variables associated with insulin production...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › Variables associated with insulin production...
questionsmedicales.fr › Équipement et fournitures › Équipement chirurgical › Organes artificiels › Pompes à perfusion › Pompes à insuline › Variables associated with insulin production...
questionsmedicales.fr › Hormones gastrointestinales › Peptides glucagon-like › Glucagon-like peptide 1 › Liraglutide › Variables associated with insulin production...