Protein condensates as aging Maxwell fluids.
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
11 12 2020
11 12 2020
Historique:
received:
05
02
2019
revised:
18
06
2019
accepted:
16
10
2020
entrez:
11
12
2020
pubmed:
12
12
2020
medline:
3
2
2021
Statut:
ppublish
Résumé
Protein condensates are complex fluids that can change their material properties with time. However, an appropriate rheological description of these fluids remains missing. We characterize the time-dependent material properties of in vitro protein condensates using laser tweezer-based active and microbead-based passive rheology. For different proteins, the condensates behave at all ages as viscoelastic Maxwell fluids. Their viscosity strongly increases with age while their elastic modulus varies weakly. No significant differences in structure were seen by electron microscopy at early and late ages. We conclude that protein condensates can be soft glassy materials that we call Maxwell glasses with age-dependent material properties. We discuss possible advantages of glassy behavior for modulation of cellular biochemistry.
Identifiants
pubmed: 33303613
pii: 370/6522/1317
doi: 10.1126/science.aaw4951
doi:
Substances chimiques
Proteins
0
Solutions
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1317-1323Subventions
Organisme : European Research Council
ID : 760067
Pays : International
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.