Whole-genome sequencing analysis of the cardiometabolic proteome.

Gene Expression Regulation Gene Regulatory Networks Genetic Predisposition to Disease Humans Multifactorial Inheritance / genetics Myocardium / metabolism Proteome / genetics Quantitative Trait Loci / genetics Risk Factors Whole Genome Sequencing

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
10 12 2020
Historique:
received: 07 04 2020
accepted: 26 10 2020
entrez: 11 12 2020
pubmed: 12 12 2020
medline: 29 12 2020
Statut: epublish

Résumé

The human proteome is a crucial intermediate between complex diseases and their genetic and environmental components, and an important source of drug development targets and biomarkers. Here, we comprehensively assess the genetic architecture of 257 circulating protein biomarkers of cardiometabolic relevance through high-depth (22.5×) whole-genome sequencing (WGS) in 1328 individuals. We discover 131 independent sequence variant associations (P < 7.45 × 10

Identifiants

DOI: 10.1038/s41467-020-20079-2 PMID: 33303764 PMC: PMC7729872
pubmed: 33303764
doi: 10.1038/s41467-020-20079-2
pii: 10.1038/s41467-020-20079-2
pmc: PMC7729872
doi:

Substances chimiques

Proteome 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6336

Subventions

Organisme : Wellcome Trust
ID : 098051
Pays : United Kingdom

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Auteurs

Arthur Gilly (A)

Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK.

Young-Chan Park (YC)

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK.
University of Cambridge, Cambridge, UK.

Grace Png (G)

Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK.

Andrei Barysenka (A)

Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.

Iris Fischer (I)

Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
ORCID: 0000-0002-5080-1223

Thea Bjørnland (T)

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK.
Department of Mathematical Sciences, Norwegian University of Science and Technology, NO-7491, Trondheim, Norway.

Lorraine Southam (L)

Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK.
Wellcome Centre for Human Genetics, Oxford, UK.

Daniel Suveges (D)

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK.
European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, CB10 1SH, UK.

Sonja Neumeyer (S)

Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.

N William Rayner (NW)

Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK.
Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

Emmanouil Tsafantakis (E)

Anogia Medical Centre, Anogia, Greece.

Maria Karaleftheri (M)

Echinos Medical Centre, Echinos, Greece.

George Dedoussis (G)

Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Moschato, Greece.

Eleftheria Zeggini (E)

Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. eleftheria.zeggini@helmholtz-muenchen.de.
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, UK. eleftheria.zeggini@helmholtz-muenchen.de.
TUM School of Medicine, Technical University of Munich and Klinikum Rechts der Isar, Munich, Germany. eleftheria.zeggini@helmholtz-muenchen.de.
ORCID: 0000-0003-4238-659X

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Whole-genome sequencing analysis of the...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Séquences d'acides nucléiques régulatrices › Réseaux de régulation génique › Whole-genome sequencing analysis of the...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Whole-genome sequencing analysis of the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Whole-genome sequencing analysis of the...
questionsmedicales.fr › Phénomènes génétiques › Modes de transmission héréditaire › Hérédité multifactorielle › Whole-genome sequencing analysis of the...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Myocarde › Whole-genome sequencing analysis of the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéome › Whole-genome sequencing analysis of the...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › Locus de caractère quantitatif › Whole-genome sequencing analysis of the...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Whole-genome sequencing analysis of the...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Séquençage du génome entier › Whole-genome sequencing analysis of the...