Extracellular Vesicles and Damage-Associated Molecular Patterns: A Pandora's Box in Health and Disease.
Alzheimer’s disease
Parkinson’s disease
damage-associated molecular patterns
endo-lysosomal system
inflammation
innate immunity
mitochondrial-derived vesicles
quality control system
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
01
09
2020
accepted:
21
10
2020
entrez:
11
12
2020
pubmed:
12
12
2020
medline:
22
6
2021
Statut:
epublish
Résumé
Sterile inflammation develops as part of an innate immunity response to molecules released upon tissue injury and collectively indicated as damage-associated molecular patterns (DAMPs). While coordinating the clearance of potential harmful stimuli, promotion of tissue repair, and restoration of tissue homeostasis, a hyper-activation of such an inflammatory response may be detrimental. The complex regulatory pathways modulating DAMPs generation and trafficking are actively investigated for their potential to provide relevant insights into physiological and pathological conditions. Abnormal circulating extracellular vesicles (EVs) stemming from altered endosomal-lysosomal system have also been reported in several age-related conditions, including cancer and neurodegeneration, and indicated as a promising route for therapeutic purposes. Along this pathway, mitochondria may dispose altered components to preserve organelle homeostasis. However, whether a common thread exists between DAMPs and EVs generation is yet to be clarified. A deeper understanding of the highly complex, dynamic, and variable intracellular and extracellular trafficking of DAMPs and EVs, including those of mitochondrial origin, is needed to unveil relevant pathogenic pathways and novel targets for drug development. Herein, we describe the mechanisms of generation of EVs and mitochondrial-derived vesicles along the endocytic pathway and discuss the involvement of the endosomal-lysosomal in cancer and neurodegeneration (i.e., Alzheimer's and Parkinson's disease).
Identifiants
pubmed: 33304353
doi: 10.3389/fimmu.2020.601740
pmc: PMC7701251
doi:
Substances chimiques
Alarmins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
601740Informations de copyright
Copyright © 2020 Picca, Guerra, Calvani, Coelho-Júnior, Landi, Bernabei, Romano, Bucci and Marzetti.
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