Clozapine and mortality: A comparison with other antipsychotics in a nationwide Danish cohort study.
clozapine
mortality
outpatient treatment
psychosis
Journal
Acta psychiatrica Scandinavica
ISSN: 1600-0447
Titre abrégé: Acta Psychiatr Scand
Pays: United States
ID NLM: 0370364
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
10
08
2020
revised:
03
11
2020
accepted:
01
12
2020
pubmed:
12
12
2020
medline:
19
8
2021
entrez:
11
12
2020
Statut:
ppublish
Résumé
To compare the mortality in people using clozapine to that of people using other antipsychotics. Danish incidence cohort of 22,110 patients with a first diagnosis of non-affective psychotic disorder (1995-2013) and a prevalence cohort of 50,881 patients ever diagnosed with such a disorder (1969-2013). Hazard ratios (HR) were calculated for the antipsychotic drug used at the time of death ("current use": incidence and prevalence cohort) and for the drug used for the longest at that moment ("cumulative use": incidence cohort), using a Cox model with adjustment for somatic comorbidity. Clozapine was the reference drug. As for current drug use, the risk of suicide was higher among users of other antipsychotics in the incidence (HR The results indicate that the use of clozapine is not associated with increased cardiovascular mortality. We found opposing trends toward a lower risk of suicide during current use of clozapine and a higher risk of suicide associated with cumulative use up to 1 year. This suggests that clozapine cessation marks a period of high risk of suicide.
Identifiants
pubmed: 33306211
doi: 10.1111/acps.13267
pmc: PMC7986383
doi:
Substances chimiques
Antipsychotic Agents
0
Clozapine
J60AR2IKIC
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
216-226Informations de copyright
© 2020 The Authors. Acta Psychiatrica Scandinavica published by John Wiley & Sons Ltd.
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