Temporal profile of serum neurofilament light in multiple sclerosis: Implications for patient monitoring.
Biomarker
brain atrophy
magnetic resonance imaging
multiple sclerosis
prognosis
serum neurofilament light chain
Journal
Multiple sclerosis (Houndmills, Basingstoke, England)
ISSN: 1477-0970
Titre abrégé: Mult Scler
Pays: England
ID NLM: 9509185
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
pubmed:
15
12
2020
medline:
26
10
2021
entrez:
14
12
2020
Statut:
ppublish
Résumé
To understand how longitudinal serum neurofilament light chain (sNfL) patterns can inform its use as a prognostic biomarker in multiple sclerosis (MS) and evaluate whether sNfL reflects MS disease activity and disease-modifying therapy usage. This was a post hoc analysis of longitudinal data and samples from the ADVANCE trial (NCT00906399) of patients with relapsing-remitting MS (RRMS). sNfL was measured every 3 months for 2 years, then every 6 months for 4 years. Regression models explored how sNfL data predicted 4-year values of brain volume, expanded disability status scale score, and T2 lesions. sNfL levels were assessed in those receiving placebo, peginterferon beta-1a, and those with disease activity. Baseline sNfL was a predictor of 4-year brain atrophy and development of new T2 lesions. Clinical ( These data support sNfL as a prognostic and disease-monitoring biomarker for RRMS.
Identifiants
pubmed: 33307998
doi: 10.1177/1352458520972573
pmc: PMC8414824
doi:
Substances chimiques
Neurofilament Proteins
0
Banques de données
ClinicalTrials.gov
['NCT00906399']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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