Diverse Routes toward Early Somites in the Mouse Embryo.

Animals Body Patterning / genetics Cell Differentiation / genetics Cell Line Chimera / embryology Embryo, Mammalian Female Fetal Proteins / genetics Gene Expression Profiling Gene Expression Regulation, Developmental / genetics Germ Cells / cytology Heterozygote Male Mesoderm / cytology Mice Mice, Inbred C57BL SOXB1 Transcription Factors / metabolism Single-Cell Analysis Somites / cytology T-Box Domain Proteins / genetics Transcriptome / genetics
Brachyury cell fate regulation developmental trajectories neuromesodermal progenitors somites

Journal

Developmental cell
ISSN: 1878-1551
Titre abrégé: Dev Cell
Pays: United States
ID NLM: 101120028

Informations de publication

Date de publication:
11 01 2021
Historique:
received: 18 04 2020
revised: 08 09 2020
accepted: 11 11 2020
pubmed: 15 12 2020
medline: 17 4 2021
entrez: 14 12 2020
Statut: ppublish

Résumé

Somite formation is foundational to creating the vertebrate segmental body plan. Here, we describe three transcriptional trajectories toward somite formation in the early mouse embryo. Precursors of the anterior-most somites ingress through the primitive streak before E7 and migrate anteriorly by E7.5, while a second wave of more posterior somites develops in the vicinity of the streak. Finally, neuromesodermal progenitors (NMPs) are set aside for subsequent trunk somitogenesis. Single-cell profiling of T

Identifiants

DOI: 10.1016/j.devcel.2020.11.013 PMID: 33308481 PMC: PMC7808755
pubmed: 33308481
pii: S1534-5807(20)30889-3
doi: 10.1016/j.devcel.2020.11.013
pmc: PMC7808755
pii:
doi:

Substances chimiques

Fetal Proteins 0
SOXB1 Transcription Factors 0
Sox2 protein, mouse 0
T-Box Domain Proteins 0
Brachyury protein EQ43SC3GDB

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

141-153.e6

Subventions

Organisme : Medical Research Council
ID : MC_PC_17230
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_12009
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M008975/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K017047/1
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : R24 DK106766
Pays : United States
Organisme : Cancer Research UK
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S008799/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 109081/Z/15/A
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors declare no competing interests.

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Auteurs

Carolina Guibentif (C)

Department of Haematology, University of Cambridge, CB2 0AW Cambridge, UK; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, CB2 0AW Cambridge, UK; Sahlgrenska Center for Cancer Research, Department of Microbiology and Immunology, University of Gothenburg, 413 90 Gothenburg, Sweden.

Jonathan A Griffiths (JA)

Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK.

Ivan Imaz-Rosshandler (I)

Department of Haematology, University of Cambridge, CB2 0AW Cambridge, UK; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, CB2 0AW Cambridge, UK.

Shila Ghazanfar (S)

Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK.

Jennifer Nichols (J)

Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, CB2 0AW Cambridge, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, CB2 3DY Cambridge, UK.

Valerie Wilson (V)

Centre for Regenerative Medicine, Institute for Stem Cell Research, School of the Biological Sciences, University of Edinburgh, EH16 4UU Edinburgh, UK. Electronic address: v.wilson@ed.ac.uk.

Berthold Göttgens (B)

Department of Haematology, University of Cambridge, CB2 0AW Cambridge, UK; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, CB2 0AW Cambridge, UK. Electronic address: bg200@cam.ac.uk.

John C Marioni (JC)

Cancer Research UK Cambridge Institute, University of Cambridge, CB2 0RE Cambridge, UK; Wellcome Sanger Institute, Wellcome Genome Campus, CB10 1SA Cambridge, UK; European Molecular Biology Laboratory, European Bioinformatics Institute, European Molecular Biology Laboratory, EBI), Wellcome Genome Campus, CB10 1SD Cambridge, UK. Electronic address: john.marioni@cruk.cam.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Diverse Routes toward Early Somites in the...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Morphogenèse › Plan d'organisation du corps › Diverse Routes toward Early Somites in the...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Diverse Routes toward Early Somites in the...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Diverse Routes toward Early Somites in the...
questionsmedicales.fr › Stades d'organismes › Chimère › Diverse Routes toward Early Somites in the...
questionsmedicales.fr › Structures de l'embryon › Embryon de mammifère › Diverse Routes toward Early Somites in the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines foetales › Diverse Routes toward Early Somites in the...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Diverse Routes toward Early Somites in the...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes au cours du développement › Diverse Routes toward Early Somites in the...
questionsmedicales.fr › Cellules › Cellules germinales › Diverse Routes toward Early Somites in the...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Hétérozygote › Diverse Routes toward Early Somites in the...
questionsmedicales.fr › Structures de l'embryon › Feuillets embryonnaires › Mésoderme › Diverse Routes toward Early Somites in the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Diverse Routes toward Early Somites in the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Diverse Routes toward Early Somites in the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription SOX › Facteurs de transcription SOX-B1 › Diverse Routes toward Early Somites in the...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Analyse sur cellule unique › Diverse Routes toward Early Somites in the...
questionsmedicales.fr › Structures de l'embryon › Feuillets embryonnaires › Mésoderme › Somites › Diverse Routes toward Early Somites in the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines à domaine boîte-T › Diverse Routes toward Early Somites in the...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Diverse Routes toward Early Somites in the...