Molecular pharmacology of P2Y receptor subtypes.

Animals Drug Delivery Systems / methods Drug Design Humans Platelet Aggregation / drug effects Purinergic P2Y Receptor Agonists / administration & dosage Purinergic P2Y Receptor Antagonists / administration & dosage Receptors, Purinergic P2Y / metabolism Signal Transduction / drug effects Vascular Diseases / drug therapy
Adenine nucleotides Agonist Antagonist Crystal structure P2Y receptors Uracil nucleotides

Journal

Biochemical pharmacology
ISSN: 1873-2968
Titre abrégé: Biochem Pharmacol
Pays: England
ID NLM: 0101032

Informations de publication

Date de publication:
05 2021
Historique:
received: 19 10 2020
revised: 06 12 2020
accepted: 07 12 2020
pubmed: 15 12 2020
medline: 15 9 2021
entrez: 14 12 2020
Statut: ppublish

Résumé

Professor Geoffrey Burnstock proposed the concept of purinergic signaling via P1 and P2 receptors. P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular adenine and uracil nucleotides. Eight mammalian P2Y receptor subtypes have been identified. They are divided into two subgroups (P2Y

Identifiants

DOI: 10.1016/j.bcp.2020.114361 PMID: 33309519
pubmed: 33309519
pii: S0006-2952(20)30597-9
doi: 10.1016/j.bcp.2020.114361
pii:
doi:

Substances chimiques

Purinergic P2Y Receptor Agonists 0
Purinergic P2Y Receptor Antagonists 0
Receptors, Purinergic P2Y 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

114361

Informations de copyright

Copyright © 2020. Published by Elsevier Inc.

Auteurs

Ivar von Kügelgen (I)

Department of Pharmacology and Toxicology, Pharma Center, University of Bonn, Bonn, Germany. Electronic address: kugelgen@uni-bonn.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Molecular pharmacology of P2Y receptor subtypes.
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Molecular pharmacology of P2Y receptor subtypes.
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › Molecular pharmacology of P2Y receptor subtypes.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Molecular pharmacology of P2Y receptor subtypes.
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hémostase › Activation plaquettaire › Agrégation plaquettaire › Molecular pharmacology of P2Y receptor subtypes.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents purinergiques › Agonistes purinergiques › Agonistes des récepteurs purinergiques P2 › Agonistes des récepteurs purinergiques P2Y › Molecular pharmacology of P2Y receptor subtypes.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents purinergiques › Antagonistes purinergiques › Antagonistes des récepteurs purinergiques P2 › Antagonistes des récepteurs purinergiques P2Y › Molecular pharmacology of P2Y receptor subtypes.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs purinergiques › Récepteurs purinergiques P2 › Récepteurs purinergiques P2Y › Molecular pharmacology of P2Y receptor subtypes.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Molecular pharmacology of P2Y receptor subtypes.
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Molecular pharmacology of P2Y receptor subtypes.