Relation of α
factor XIII
fibrinogen
fibrinolysis
spondyloarthritis
vascular endothelial growth factor
α2-antiplasmin
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
09 Dec 2020
09 Dec 2020
Historique:
received:
18
11
2020
revised:
04
12
2020
accepted:
07
12
2020
entrez:
15
12
2020
pubmed:
16
12
2020
medline:
3
3
2021
Statut:
epublish
Résumé
Coagulation and fibrinolysis are interrelated with the expression of vascular endothelial growth factor (VEGF), which frequently is increased in axial spondyloarthritis (axSpA). We tested whether (i) α One hundred and eighty-six axSpA patients from the German Spondyloarthritis Inception Cohort were genotyped, characterized for VEGF levels, and statistically analyzed. The association between VEGF and radiographic spinal progression was assessed in dependence on genetic background in stratified analyses. A2AP 6Trp carriage was associated with VEGF elevation (OR: 2.37, 95% CI: 1.06-5.29) and VEGF levels (6Trp, 455 ± 334 pg/mL; 6Arg/Arg, 373 ± 293 pg/mL; The A2AP Arg6Trp genotype seems to influence VEGF levels in axSpA. The predictive value of VEGF elevations in respect of radiographic spinal progression in axSpA depends on FGA genotypes.
Identifiants
pubmed: 33317138
pii: ijms21249383
doi: 10.3390/ijms21249383
pmc: PMC7764219
pii:
doi:
Substances chimiques
Vascular Endothelial Growth Factor A
0
alpha-2-Antiplasmin
0
Factor VIII
9001-27-8
Fibrinogen
9001-32-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Bundesministerium für Bildung und Forschung
ID : ArthroMark 01EC1009A
Organisme : Bundesministerium für Bildung und Forschung
ID : ArthroMark II 01EC1401A
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