Human breast milk as source of sphingolipids for newborns: comparison with infant formulas and commercial cow's milk.
Ceramide
Cow’s milk
Human breast milk
Infant formulas
Lipidomic
Sphingomyelin
Journal
Journal of translational medicine
ISSN: 1479-5876
Titre abrégé: J Transl Med
Pays: England
ID NLM: 101190741
Informations de publication
Date de publication:
14 12 2020
14 12 2020
Historique:
received:
30
07
2020
accepted:
27
11
2020
entrez:
15
12
2020
pubmed:
16
12
2020
medline:
15
5
2021
Statut:
epublish
Résumé
In the past two decades, sphingolipids have become increasingly appreciated as bioactive molecules playing important roles in a wide array of pathophysiology mechanisms. Despite advances in the field, sphingolipids as nutrients remain little explored. Today the research is starting to move towards the study of the sphingomyelin content in human breast milk, recommended for feeding infants. In the present study, we performed a lipidomic analysis in human breast milk in relation with maternal diet during pregnancy, in infant formulas, and in commercial whole and semi-skimmed milks for adults. Mediterranean, carnivorous and vegetarian diets were considered. The results showed that total sphingomyelin, ceramide and dihydroceramide species are independent on the diet. Interestingly, the milk sphingolipid composition is species-specific. In fact, infant formulas and commercial milks for adults have a lower level of total sphingomyelin and ceramide content than human breast milk with very different composition of each sphingolipid species. We conclude that human breast milk is a better source of sphingolipids than infant formulas for baby nutrition with potential implications for the brain development and cognitive functions.
Sections du résumé
BACKGROUND
In the past two decades, sphingolipids have become increasingly appreciated as bioactive molecules playing important roles in a wide array of pathophysiology mechanisms. Despite advances in the field, sphingolipids as nutrients remain little explored. Today the research is starting to move towards the study of the sphingomyelin content in human breast milk, recommended for feeding infants.
METHODS
In the present study, we performed a lipidomic analysis in human breast milk in relation with maternal diet during pregnancy, in infant formulas, and in commercial whole and semi-skimmed milks for adults. Mediterranean, carnivorous and vegetarian diets were considered.
RESULTS
The results showed that total sphingomyelin, ceramide and dihydroceramide species are independent on the diet. Interestingly, the milk sphingolipid composition is species-specific. In fact, infant formulas and commercial milks for adults have a lower level of total sphingomyelin and ceramide content than human breast milk with very different composition of each sphingolipid species.
CONCLUSIONS
We conclude that human breast milk is a better source of sphingolipids than infant formulas for baby nutrition with potential implications for the brain development and cognitive functions.
Identifiants
pubmed: 33317546
doi: 10.1186/s12967-020-02641-0
pii: 10.1186/s12967-020-02641-0
pmc: PMC7734711
doi:
Substances chimiques
Sphingolipids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
481Références
Chem Phys Lipids. 2018 Sep;215:84-95
pubmed: 30005889
Am J Clin Nutr. 2010 Mar;91(3):672-8
pubmed: 20071649
Front Neurol. 2020 May 21;11:437
pubmed: 32528400
Neuroimage. 2014 Oct 15;100:703-5
pubmed: 25064669
Blood. 2012 Mar 15;119(11):2478-88
pubmed: 22279055
J Transl Med. 2013 May 01;11:109
pubmed: 23634702
Nutrients. 2018 Jan 31;10(2):
pubmed: 29385065
J Nutr Biochem. 2019 Nov;73:108224
pubmed: 31654895
J Nutr Biochem. 2019 Mar;65:128-138
pubmed: 30685581
Int J Neuropsychopharmacol. 2018 Mar 1;21(3):207-215
pubmed: 29040586
Nutrients. 2019 Jan 22;11(2):
pubmed: 30678181
PLoS One. 2015 Jul 31;10(7):e0133181
pubmed: 26230734
J Physiol. 2016 Oct 15;594(20):5899-5921
pubmed: 27357166
Mol Genet Metab. 2020 Feb;129(2):111-116
pubmed: 31494022
Biochem J. 2012 Feb 1;441(3):789-802
pubmed: 22248339
Int J Mol Sci. 2018 Nov 01;19(11):
pubmed: 30388783
Chem Phys Lipids. 2018 Nov;216:114-131
pubmed: 30194926
Neurosci Lett. 2015 Mar 4;589:83-7
pubmed: 25556686
eNeuro. 2019 Aug 6;6(4):
pubmed: 31324675
Mol Cell Biol. 2012 Aug;32(16):3242-52
pubmed: 22688512
Hum Brain Mapp. 2014 Sep;35(9):4475-87
pubmed: 24578096
J Nutr. 1999 Jul;129(7):1239-50
pubmed: 10395583
Mol Genet Metab. 2003 Jun;79(2):104-9
pubmed: 12809640
J Neurol Psychol. 2017 Dec;5(1):
pubmed: 30338269
Obesity (Silver Spring). 2012 May;20(5):923-31
pubmed: 22282043
Neurochem Res. 2017 Feb;42(2):321-336
pubmed: 27766461
Crit Rev Food Sci Nutr. 2016 Aug 17;56(11):1880-92
pubmed: 26075805
Front Neurosci. 2015 Aug 25;9:300
pubmed: 26379487
EMBO J. 1999 Apr 1;18(7):1761-71
pubmed: 10202140
Leukemia. 2010 May;24(5):976-85
pubmed: 20357827
Science. 2010 Jan 1;327(5961):46-50
pubmed: 20044567
Molecules. 2020 Jun 24;25(12):
pubmed: 32599866
Metabolites. 2019 Oct 28;9(11):
pubmed: 31661817
Biochim Biophys Acta Biomembr. 2020 Feb 1;1862(2):183077
pubmed: 31805269
Cell Physiol Biochem. 2014;34(1):111-8
pubmed: 24977485
Drug Deliv. 2019 Dec;26(1):237-243
pubmed: 30883241
Pediatr Res. 2003 Apr;53(4):589-93
pubmed: 12612207
Mediators Inflamm. 2018 May 6;2018:7464702
pubmed: 29853792