The tricuspid valve also maladapts as shown in sheep with biventricular heart failure.
Adaptation, Physiological
Animals
Disease Models, Animal
Energy Metabolism
Extracellular Matrix
/ genetics
Fibrillar Collagens
/ genetics
Gene Expression Regulation
Heart Failure
/ complications
Hemodynamics
Male
Sheep, Domestic
Signal Transduction
Tricuspid Valve
/ diagnostic imaging
Tricuspid Valve Insufficiency
/ diagnostic imaging
Ventricular Function, Left
Ventricular Function, Right
biomechanics
disease
heart valve
medicine
regurgitation
sheep
surgery
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
15 12 2020
15 12 2020
Historique:
received:
09
10
2020
accepted:
02
12
2020
entrez:
15
12
2020
pubmed:
16
12
2020
medline:
17
3
2021
Statut:
epublish
Résumé
Over 1.6 million Americans suffer from significant tricuspid valve leakage. In most cases this leakage is designated as secondary. Thus, valve dysfunction is assumed to be due to valve-extrinsic factors. We challenge this paradigm and hypothesize that the tricuspid valve maladapts in those patients rendering the valve at least partially culpable for its dysfunction. As a first step in testing this hypothesis, we set out to demonstrate that the tricuspid valve maladapts in disease. To this end, we induced biventricular heart failure in sheep that developed tricuspid valve leakage. In the anterior leaflets of those animals, we investigated maladaptation on multiple scales. We demonstrated alterations on the protein and cell-level, leading to tissue growth, thickening, and stiffening. These data provide a new perspective on a poorly understood, yet highly prevalent disease. Our findings may motivate novel therapy options for many currently untreated patients with leaky tricuspid valves.
Identifiants
pubmed: 33320094
doi: 10.7554/eLife.63855
pii: 63855
pmc: PMC7738185
doi:
pii:
Substances chimiques
Fibrillar Collagens
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHLBI NIH HHS
ID : F31 HL145976
Pays : United States
Organisme : American Heart Association
ID : 18CDA34120028
Pays : International
Informations de copyright
© 2020, Meador et al.
Déclaration de conflit d'intérêts
WM, MM, GS, MM, TJ, XW, CL, TT No competing interests declared, MR Consultant for Edwards Lifesciences
Références
Circulation. 2008 Sep 30;118(14 Suppl):S243-9
pubmed: 18824762
J Am Coll Cardiol. 2015 Jun 2;65(21):2331-6
pubmed: 26022823
J Thorac Cardiovasc Surg. 2014 Nov;148(5):1962-4
pubmed: 25444187
Eur Heart J. 2017 Apr 21;38(16):1261
pubmed: 28073862
Circulation. 2008 Aug 19;118(8):797-9
pubmed: 18711022
J Thorac Cardiovasc Surg. 2005 Sep;130(3):783-90
pubmed: 16153929
Acta Biomater. 2020 Jan 1;101:403-413
pubmed: 31614209
Circ Cardiovasc Imaging. 2017 Nov;10(11):
pubmed: 29042413
Nat Protoc. 2006;1(6):2856-60
pubmed: 17406544
J Am Coll Cardiol. 2016 Jan 26;67(3):275-87
pubmed: 26796392
Circ Cardiovasc Imaging. 2015 May;8(5):
pubmed: 25977303
J Am Coll Cardiol. 2017 Sep 5;70(10):1232-1244
pubmed: 28859786
Nat Rev Cardiol. 2015 Dec;12(12):689-710
pubmed: 26483167
Bioengineering (Basel). 2019 May 22;6(2):
pubmed: 31121881
J Am Coll Cardiol. 2004 Feb 4;43(3):405-9
pubmed: 15013122
Circulation. 2009 Jul 28;120(4):334-42
pubmed: 19597052
Eur Heart J Cardiovasc Imaging. 2015 Mar;16(3):286-7
pubmed: 25617031
JACC Cardiovasc Interv. 2018 Feb 26;11(4):407-408
pubmed: 29361449
Circulation. 1967 Apr;35(4 Suppl):I63-9
pubmed: 6024041
J Biomech. 2019 Jan 23;83:16-27
pubmed: 30497683
Cell Signal. 2000 Oct;12(9-10):607-17
pubmed: 11080612
J Proteome Res. 2013 Oct 4;12(10):4302-15
pubmed: 23964713
Biomech Model Mechanobiol. 2012 Mar;11(3-4):461-73
pubmed: 21744269
Circulation. 2003 Oct 14;108(15):1804-8
pubmed: 14530190
J Thorac Cardiovasc Surg. 2019 Nov 23;:
pubmed: 31926731
Circ Cardiovasc Interv. 2017 Jul;10(7):
pubmed: 28698289
Circ Cardiovasc Imaging. 2012 Jan;5(1):43-50
pubmed: 22109981
Am J Physiol Heart Circ Physiol. 2015 Nov;309(9):H1565-78
pubmed: 26371175
Biochem Biophys Res Commun. 2014 Apr 18;446(4):870-5
pubmed: 24632204
J Am Coll Cardiol. 2013 Apr 30;61(17):1809-16
pubmed: 23500248
Compr Physiol. 2016 Sep 15;6(4):1743-1780
pubmed: 27783858
Interact Cardiovasc Thorac Surg. 2017 Jun 1;24(6):905-910
pubmed: 28329164
Circulation. 2009 Sep 15;120(11 Suppl):S112-9
pubmed: 19752355
Am J Pathol. 2007 Nov;171(5):1407-18
pubmed: 17823281
Methods Enzymol. 2011;499:55-75
pubmed: 21683249
Cardiovasc Res. 2006 Dec 1;72(3):375-83
pubmed: 17010955
Minerva Cardioangiol. 2017 Oct;65(5):469-479
pubmed: 28398019
J R Soc Interface. 2017 Oct;14(135):
pubmed: 29046338
Front Med (Lausanne). 2019 Feb 12;6:25
pubmed: 30809526
Circulation. 2018 Jul 24;138(4):377-393
pubmed: 29588317
J Am Coll Cardiol. 2012 Feb 21;59(8):703-10
pubmed: 22340261
J Mech Behav Biomed Mater. 2012 Nov;15:208-17
pubmed: 23159489
Circulation. 1971 Mar;43(3):333-48
pubmed: 5544987
Circ Res. 2004 Aug 6;95(3):253-60
pubmed: 15217906
Arterioscler Thromb Vasc Biol. 1996 Apr;16(4):523-32
pubmed: 8624774
Biochim Biophys Acta. 2001 Mar 26;1535(3):221-35
pubmed: 11278163
Acta Biomater. 2019 Sep 15;96:368-384
pubmed: 31260822
Acta Biomater. 2020 Jan 15;102:100-113
pubmed: 31760220
J Am Coll Cardiol. 2005 Jan 4;45(1):54-61
pubmed: 15629373
J Thorac Cardiovasc Surg. 2012 May;143(5):1050-5
pubmed: 21798563
Circulation. 2009 May 26;119(20):2718-25
pubmed: 19470900
J Am Heart Assoc. 2018 Nov 6;7(21):e009777
pubmed: 30571381