Recombination and Pol ζ Rescue Defective DNA Replication upon Impaired CMG Helicase-Pol ε Interaction.
Cell Survival
/ genetics
DNA Helicases
/ metabolism
DNA Polymerase II
/ genetics
DNA Replication
/ genetics
DNA-Binding Proteins
/ genetics
DNA-Directed DNA Polymerase
/ metabolism
Frameshifting, Ribosomal
/ genetics
G2 Phase Cell Cycle Checkpoints
/ genetics
Minichromosome Maintenance Proteins
/ metabolism
Mutagenesis
Mutation
Mutation Rate
Nuclear Proteins
/ genetics
Protein Binding
Rad52 DNA Repair and Recombination Protein
/ genetics
Recombination, Genetic
/ genetics
Saccharomyces cerevisiae
/ genetics
Saccharomyces cerevisiae Proteins
/ genetics
Synthetic Lethal Mutations
/ genetics
CMGE helicase-polymerase complex
DNA polymerase epsilon
DNA replication fidelity
DRIM
GINS complex
PSF1/GINS1
Pol ε
Pol ζ
genetic instability
polymerase zeta
recombination
repeat tracts instability
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
13 Dec 2020
13 Dec 2020
Historique:
received:
20
11
2020
revised:
06
12
2020
accepted:
09
12
2020
entrez:
16
12
2020
pubmed:
17
12
2020
medline:
20
3
2021
Statut:
epublish
Résumé
The CMG complex (Cdc45, Mcm2-7, GINS (Psf1, 2, 3, and Sld5)) is crucial for both DNA replication initiation and fork progression. The CMG helicase interaction with the leading strand DNA polymerase epsilon (Pol ε) is essential for the preferential loading of Pol ε onto the leading strand, the stimulation of the polymerase, and the modulation of helicase activity. Here, we analyze the consequences of impaired interaction between Pol ε and GINS in
Identifiants
pubmed: 33322195
pii: ijms21249484
doi: 10.3390/ijms21249484
pmc: PMC7762974
pii:
doi:
Substances chimiques
CDC45 protein, S cerevisiae
0
DNA-Binding Proteins
0
Nuclear Proteins
0
PFS1 protein, S cerevisiae
0
RAD52 protein, S cerevisiae
0
Rad52 DNA Repair and Recombination Protein
0
Saccharomyces cerevisiae Proteins
0
DNA polymerase zeta
EC 2.7.7.-
DNA Polymerase II
EC 2.7.7.7
DNA-Directed DNA Polymerase
EC 2.7.7.7
DNA Helicases
EC 3.6.4.-
Minichromosome Maintenance Proteins
EC 3.6.4.12
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Narodowym Centrum Nauki
ID : 2017/26/M/NZ3/01044
Organisme : Fundacja na rzecz Nauki Polskiej
ID : TEAM/2011-8/1
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