Efficacy of Spice Supplementation in Rheumatoid Arthritis: A Systematic Literature Review.
Adult
Antirheumatic Agents
/ administration & dosage
Arthritis, Rheumatoid
/ therapy
Cinnamomum zeylanicum
/ chemistry
Crocus
/ chemistry
Dietary Supplements
Female
Garlic
/ chemistry
Zingiber officinale
/ chemistry
Humans
Male
Middle Aged
Randomized Controlled Trials as Topic
Spices
Treatment Outcome
cinnamon
curcuma
disease activity
garlic
ginger
rheumatoid arthritis
saffron
spice
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
11 Dec 2020
11 Dec 2020
Historique:
received:
22
11
2020
revised:
07
12
2020
accepted:
08
12
2020
entrez:
16
12
2020
pubmed:
17
12
2020
medline:
24
4
2021
Statut:
epublish
Résumé
Spices, i.e., curcumin, ginger, saffron, and cinnamon, have a thousand-year history of medicinal use in Asia. Modern medicine has begun to explore their therapeutic properties during the last few decades. We aimed to perform a systematic literature review (SLR) of randomized controlled trials (RCTs) assessing the effect of spice supplementation on symptoms and disease activity in patients with chronic inflammatory rheumatic diseases (rheumatoid arthritis (RA), spondylarthritis, or psoriatic arthritis). An SLR of RCTs, reviews, and meta-analyses was performed, searching for articles in MEDLINE/PubMed. Abstracts from international rheumatology and nutrition congresses (2017-2020) were also scrutinized. The risk of bias of the selected studies was evaluated using the Cochrane Collaboration's tool and the Jadad scale. Altogether, six studies, assessing the use of spice supplementation only in RA patients, were included: one on garlic supplementation, two on curcumin, one on ginger, one on cinnamon, and one on saffron supplementation. Garlic, ginger, cinnamon, or saffron supplementation was associated with a decrease in RA clinical activity. However, several points limit the external validity of these studies. No conclusion on the impact of curcumin supplementation on RA activity could be drawn due to low-quality studies. Garlic, ginger, cinnamon, and saffron supplementation could have a beneficial effect on RA activity, but the risk of bias of these studies is difficult to assess and data are too limited to recommend them in daily practice.
Sections du résumé
BACKGROUND
BACKGROUND
Spices, i.e., curcumin, ginger, saffron, and cinnamon, have a thousand-year history of medicinal use in Asia. Modern medicine has begun to explore their therapeutic properties during the last few decades. We aimed to perform a systematic literature review (SLR) of randomized controlled trials (RCTs) assessing the effect of spice supplementation on symptoms and disease activity in patients with chronic inflammatory rheumatic diseases (rheumatoid arthritis (RA), spondylarthritis, or psoriatic arthritis).
METHODS
METHODS
An SLR of RCTs, reviews, and meta-analyses was performed, searching for articles in MEDLINE/PubMed. Abstracts from international rheumatology and nutrition congresses (2017-2020) were also scrutinized. The risk of bias of the selected studies was evaluated using the Cochrane Collaboration's tool and the Jadad scale.
RESULTS
RESULTS
Altogether, six studies, assessing the use of spice supplementation only in RA patients, were included: one on garlic supplementation, two on curcumin, one on ginger, one on cinnamon, and one on saffron supplementation. Garlic, ginger, cinnamon, or saffron supplementation was associated with a decrease in RA clinical activity. However, several points limit the external validity of these studies. No conclusion on the impact of curcumin supplementation on RA activity could be drawn due to low-quality studies.
CONCLUSIONS
CONCLUSIONS
Garlic, ginger, cinnamon, and saffron supplementation could have a beneficial effect on RA activity, but the risk of bias of these studies is difficult to assess and data are too limited to recommend them in daily practice.
Identifiants
pubmed: 33322318
pii: nu12123800
doi: 10.3390/nu12123800
pmc: PMC7764619
pii:
doi:
Substances chimiques
Antirheumatic Agents
0
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Références
Nutrients. 2020 Jan 06;12(1):
pubmed: 31935866
Biochem Pharmacol. 2006 May 14;71(10):1397-421
pubmed: 16563357
Food Chem Toxicol. 2008 Feb;46(2):409-20
pubmed: 17950516
Pharmacology. 1994 Nov;49(5):314-8
pubmed: 7862743
Phytother Res. 2020 Nov;34(11):2953-2962
pubmed: 32478922
J Med Food. 2010 Feb;13(1):156-62
pubmed: 20136450
BMJ. 2009 Jul 21;339:b2535
pubmed: 19622551
Biotechnol Adv. 2020 Jan - Feb;38:107343
pubmed: 30716389
Phytother Res. 2020 Jul;34(7):1650-1658
pubmed: 32048365
Curr Opin Rheumatol. 2019 Sep;31(5):517-524
pubmed: 31268867
J Med Food. 2017 Oct;20(10):1022-1030
pubmed: 28850308
Joint Bone Spine. 2019 Mar;86(2):135-150
pubmed: 30315988
BMC Pharmacol. 2002 Mar 15;2:7
pubmed: 11914135
J Am Coll Nutr. 2018 May 3;:1-6
pubmed: 29722610
PLoS One. 2013 Sep 16;8(9):e73877
pubmed: 24066081
J AOAC Int. 2019 Mar 1;102(2):395-411
pubmed: 30651162
Mol Nutr Food Res. 2013 Nov;57(11):2049-60
pubmed: 23766070
BMC Complement Med Ther. 2020 Nov 9;20(1):333
pubmed: 33167948
Curr Opin Pharmacol. 2007 Jun;7(3):344-51
pubmed: 17475558
Planta Med. 2004 Sep;70(9):823-7
pubmed: 15503352
Med J Islam Repub Iran. 2019 Dec 27;33:154
pubmed: 32280660
Cochrane Database Syst Rev. 2020 Jul 16;7:CD008037
pubmed: 32671834
Int J Clin Pract. 2020 Jul;74(7):e13498
pubmed: 32159257
Evid Based Complement Alternat Med. 2012;2012:429320
pubmed: 22536283
J Periodontal Res. 2015 Jun;50(3):380-8
pubmed: 25203776
Gene. 2019 May 25;698:179-185
pubmed: 30844477
Clin Nutr. 2019 Apr;38(2):594-602
pubmed: 29661513
Ann Rheum Dis. 2020 Jun;79(6):685-699
pubmed: 31969328
J Med Food. 2016 Aug;19(8):717-29
pubmed: 27533649
Mol Nutr Food Res. 2016 Dec;60(12):2576-2586
pubmed: 27487982
Genes Nutr. 2019 May 22;14:18
pubmed: 31143299
Phytother Res. 2012 Nov;26(11):1719-25
pubmed: 22407780