Altered Innate-like T Cell Development in Vα14-Jα18 TCRα Transgenic Mice.
Animals
Antigens, CD1d
/ genetics
CD8-Positive T-Lymphocytes
/ immunology
Cell Differentiation
/ immunology
Galactosylceramides
/ pharmacology
Mice
Mice, Inbred C57BL
Mice, Transgenic
Models, Animal
Natural Killer T-Cells
/ cytology
Receptors, Antigen, T-Cell
/ genetics
T-Lymphocytes, Helper-Inducer
/ immunology
Thymus Gland
/ cytology
Journal
ImmunoHorizons
ISSN: 2573-7732
Titre abrégé: Immunohorizons
Pays: United States
ID NLM: 101708159
Informations de publication
Date de publication:
15 12 2020
15 12 2020
Historique:
received:
18
11
2020
accepted:
28
11
2020
entrez:
16
12
2020
pubmed:
17
12
2020
medline:
10
11
2021
Statut:
epublish
Résumé
CD1d-restricted invariant NKT (iNKT) cells are innate-like T cells that respond to glycolipids, a class of Ags that are invisible to conventional T cells. iNKT cells develop in the thymus where they receive strong "agonist" TCR signals. During their ontogeny, iNKT cells differentiate into discrete iNKT1, iNKT2, and iNKT17 effector subsets akin to helper CD4 T cells. In this study, we found that transgenic (Tg) expression of the canonical Vα14-Jα18 TCRα-chain at the double-positive thymocyte stage led to premature iNKT cell development and a cell-intrinsic bias toward iNKT2 cells, due to increased TCR signaling upon selection. Consistent with the strong iNKT2 bias, innate memory CD8
Identifiants
pubmed: 33323387
pii: 4/12/797
doi: 10.4049/immunohorizons.2000100
doi:
Substances chimiques
Antigens, CD1d
0
Galactosylceramides
0
Receptors, Antigen, T-Cell
0
alpha-galactosylceramide
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
797-808Subventions
Organisme : CIHR
ID : MOP–114911
Pays : Canada
Informations de copyright
Copyright © 2020 The Authors.