Genome-wide Copy-number Alterations in Circulating Tumor DNA as a Novel Biomarker for Patients with High-grade Serous Ovarian Cancer.
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
Circulating Tumor DNA
Combined Modality Therapy
Cystadenocarcinoma, Serous
/ blood
DNA Copy Number Variations
Diagnostic Imaging
Female
Genome-Wide Association Study
Humans
Liquid Biopsy
/ methods
Middle Aged
Neoplasm Grading
Neoplasm Staging
Ovarian Neoplasms
/ blood
Sensitivity and Specificity
Treatment Outcome
Young Adult
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
01 05 2021
01 05 2021
Historique:
received:
01
09
2020
revised:
27
10
2020
accepted:
11
12
2020
pubmed:
17
12
2020
medline:
17
3
2022
entrez:
16
12
2020
Statut:
ppublish
Résumé
High-grade serous epithelial ovarian cancer (HGS-EOC) is defined by high levels of somatic copy-number alterations (SCNA) with marked spatial and temporal tumor heterogeneity. Biomarkers serving to monitor drug response and detect disease recurrence are lacking, a fact which reflects an unmet clinical need. A total of 185 plasma samples and 109 matched tumor biopsies were collected from 46 patients with HGS-EOC, and analyzed by shallow whole-genome sequencing (sWGS). The percentage of tumor fraction (TF) in the plasma was used to study the biological features of the disease at the time of diagnosis (T0) and correlated with patients' survival. Longitudinal analysis of TF was correlated with CA-125 levels and radiological images to monitor disease recurrence. Gain in the clonal regions, Our results support the notion that sWGS is an inexpensive and useful tool for the genomic analysis of ctDNA in patients with HGS-EOC to monitor disease evolution and to anticipate relapse better than serum CA-125, the routinely used clinical biomarker.
Identifiants
pubmed: 33323403
pii: 1078-0432.CCR-20-3345
doi: 10.1158/1078-0432.CCR-20-3345
doi:
Substances chimiques
Biomarkers, Tumor
0
Circulating Tumor DNA
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2549-2559Commentaires et corrections
Type : CommentIn
Informations de copyright
©2020 American Association for Cancer Research.
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