Hypusination Orchestrates the Antimicrobial Response of Macrophages.
Citrobacter rodentium
Helicobacter pylori
bacterial infection
gastrointestinal tract
hypusine
innate immunity
macrophages
polyamines
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
15 12 2020
15 12 2020
Historique:
received:
10
04
2020
revised:
28
10
2020
accepted:
18
11
2020
entrez:
16
12
2020
pubmed:
17
12
2020
medline:
22
12
2021
Statut:
ppublish
Résumé
Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form the amino acid hypusine. Hypusinated EIF5A (EIF5A
Identifiants
pubmed: 33326776
pii: S2211-1247(20)31499-6
doi: 10.1016/j.celrep.2020.108510
pmc: PMC7812972
mid: NIHMS1657017
pii:
doi:
Substances chimiques
Anti-Infective Agents
0
hypusine
3874VXF092
Lysine
K3Z4F929H6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
108510Subventions
Organisme : NCI NIH HHS
ID : P01 CA028842
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA190612
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK060581
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI142042
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK058404
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI138932
Pays : United States
Organisme : NIH HHS
ID : S10 OD023514
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA116087
Pays : United States
Organisme : BLRD VA
ID : I01 BX001453
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK124906
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA068485
Pays : United States
Organisme : CSRD VA
ID : I01 CX002171
Pays : United States
Informations de copyright
Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of Interests K.T.W. serves as an associate editor for the journal Gastroenterology. He receives compensation for this work from the American Gastroenterological Association. This position is not related to this study.