Design, synthesis and biological evaluation of thioether-containing lenalidomide and pomalidomide derivatives with anti-multiple myeloma activity.

Animals Cell Proliferation / drug effects Drug Design Female Humans Immunologic Factors / pharmacology Lenalidomide / chemical synthesis Mice Mice, SCID Multiple Myeloma / drug therapy Sulfides / chemistry Thalidomide / analogs & derivatives Xenograft Model Antitumor Assays
Late-stage sulfuration Lenalidomide MM.1S Multiple myeloma

Journal

European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510

Informations de publication

Date de publication:
01 Jan 2021
Historique:
received: 14 08 2020
revised: 30 09 2020
accepted: 03 10 2020
entrez: 17 12 2020
pubmed: 18 12 2020
medline: 24 4 2021
Statut: ppublish

Résumé

Lenalidomide and its analogs are well-known for treating multiple myeloma. In this work, designed sulfide-modified lenalidomide and pomalidomide were synthesized and evaluated. The anti-proliferative activity against MM.1S cell line of 3ak (IC

Identifiants

DOI: 10.1016/j.ejmech.2020.112912 PMID: 33328101
pubmed: 33328101
pii: S0223-5234(20)30884-9
doi: 10.1016/j.ejmech.2020.112912
pii:
doi:

Substances chimiques

Immunologic Factors 0
Sulfides 0
Thalidomide 4Z8R6ORS6L
pomalidomide D2UX06XLB5
Lenalidomide F0P408N6V4

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

112912

Informations de copyright

Copyright © 2020 Elsevier Masson SAS. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Yuhong Wang (Y)

Shanghai Key Laboratory of Green Chemistry and Chemical Process, Department of Chemistry, East China Normal University, 3663 North Zhongshan Rd., Shanghai, 200062, PR China.

Tian Mi (T)

National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, PR China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, PR China.

Yiming Li (Y)

Shanghai Key Laboratory of Green Chemistry and Chemical Process, Department of Chemistry, East China Normal University, 3663 North Zhongshan Rd., Shanghai, 200062, PR China.

Weijuan Kan (W)

National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, PR China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, PR China.

Gaoya Xu (G)

National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, PR China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, PR China.

Jingya Li (J)

National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, PR China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, PR China.

Yubo Zhou (Y)

National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, PR China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, PR China.

Jia Li (J)

National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, PR China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, PR China. Electronic address: jli@simm.ac.cn.

Xuefeng Jiang (X)

Shanghai Key Laboratory of Green Chemistry and Chemical Process, Department of Chemistry, East China Normal University, 3663 North Zhongshan Rd., Shanghai, 200062, PR China; State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, PR China. Electronic address: xfjiang@chem.ecnu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Design, synthesis and biological evaluation of...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Design, synthesis and biological evaluation of...
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questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Isoindoles › Phtalimides › Lénalidomide › Design, synthesis and biological evaluation of...
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questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Paraprotéinémies › Myélome multiple › Design, synthesis and biological evaluation of...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfures › Design, synthesis and biological evaluation of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Isoindoles › Phtalimides › Thalidomide › Design, synthesis and biological evaluation of...
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