Plasma exosomal
Journal
Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086
Informations de publication
Date de publication:
16 12 2020
16 12 2020
Historique:
received:
09
01
2019
revised:
07
02
2020
accepted:
25
11
2020
entrez:
17
12
2020
pubmed:
18
12
2020
medline:
24
6
2021
Statut:
ppublish
Résumé
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe drug-induced cutaneous reactions characterized by keratinocyte apoptosis. Exosomes are nanometer-sized membranous vesicles in body fluids. They contain functional proteins, mRNAs, and miRNAs, which induce immune dysfunction and influence disease progression. However, their roles and mechanisms in SJS/TEN remain unknown. Our results demonstrate that exosomes isolated from the plasma of patients with SJS/TEN were 30 to 200 nm in diameter and expressed CD9, CD63, CD81, and TSG101 exosome marker proteins.
Identifiants
pubmed: 33328332
pii: 12/574/eaaw6142
doi: 10.1126/scitranslmed.aaw6142
pii:
doi:
Substances chimiques
MIRN375 microRNA, human
0
MicroRNAs
0
X-Linked Inhibitor of Apoptosis Protein
0
XIAP protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.