Measuring DNA mechanics on the genome scale.

Biomechanical Phenomena Chromatin Assembly and Disassembly Codon / genetics DNA, Fungal / chemistry Genome, Fungal Nucleosomes / chemistry Pliability Saccharomyces cerevisiae / genetics Saccharomyces cerevisiae Proteins / metabolism Transcription Initiation Site

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
01 2021
Historique:
received: 11 04 2020
accepted: 21 10 2020
pubmed: 18 12 2020
medline: 27 2 2021
entrez: 17 12 2020
Statut: ppublish

Résumé

Mechanical deformations of DNA such as bending are ubiquitous and have been implicated in diverse cellular functions

Identifiants

DOI: 10.1038/s41586-020-03052-3 PMID: 33328628 PMC: PMC7855230
pubmed: 33328628
doi: 10.1038/s41586-020-03052-3
pii: 10.1038/s41586-020-03052-3
pmc: PMC7855230
mid: NIHMS1640017
doi:

Substances chimiques

Codon 0
DNA, Fungal 0
INO80 complex, S cerevisiae 0
Nucleosomes 0
Saccharomyces cerevisiae Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

462-467

Subventions

Organisme : NIH HHS
ID : GM122569
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM130393
Pays : United States
Organisme : European Research Council
ID : 833613
Pays : International
Organisme : NIGMS NIH HHS
ID : R35 GM122569
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA163336
Pays : United States

Commentaires et corrections

Type : CommentIn
Type : CommentIn
Type : CommentIn

Références

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Auteurs

Aakash Basu (A)

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
ORCID: 0000-0003-2446-4937

Dmitriy G Bobrovnikov (DG)

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
ORCID: 0000-0003-0696-6829

Zan Qureshi (Z)

Department of Biophysics, Johns Hopkins University, Baltimore, MD, USA.

Tunc Kayikcioglu (T)

Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Thuy T M Ngo (TTM)

Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
ORCID: 0000-0002-0751-8983

Anand Ranjan (A)

Department of Biology, Johns Hopkins University, Baltimore, MD, USA.

Sebastian Eustermann (S)

Department of Biochemistry, Ludwig-Maximilians-Universität, Munich, Germany.
Gene Center, Ludwig-Maximilians-Universität, Munich, Germany.

Basilio Cieza (B)

Department of Biophysics, Johns Hopkins University, Baltimore, MD, USA.

Michael T Morgan (MT)

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Miroslav Hejna (M)

Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
ORCID: 0000-0002-3613-1796

H Tomas Rube (HT)

Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Karl-Peter Hopfner (KP)

Department of Biochemistry, Ludwig-Maximilians-Universität, Munich, Germany.
Gene Center, Ludwig-Maximilians-Universität, Munich, Germany.
ORCID: 0000-0002-4528-8357

Cynthia Wolberger (C)

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
ORCID: 0000-0001-8578-2969

Jun S Song (JS)

Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Cancer Center at Illinois, University of Illinois, Urbana, IL, USA.

Taekjip Ha (T)

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA. tjha@jhu.edu.
Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL, USA. tjha@jhu.edu.
Department of Biophysics, Johns Hopkins University, Baltimore, MD, USA. tjha@jhu.edu.
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA. tjha@jhu.edu.
Howard Hughes Medical Institute, Baltimore, MD, USA. tjha@jhu.edu.
ORCID: 0000-0003-2195-6258

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiques › Phénomènes mécaniques › Phénomènes biomécaniques › Measuring DNA mechanics on the genome scale.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Assemblage et désassemblage de la chromatine › Measuring DNA mechanics on the genome scale.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Codon › Measuring DNA mechanics on the genome scale.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN fongique › Measuring DNA mechanics on the genome scale.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome microbien › Génome fongique › Measuring DNA mechanics on the genome scale.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Nucléosomes › Measuring DNA mechanics on the genome scale.
questionsmedicales.fr › Phénomènes physiques › Phénomènes mécaniques › Flexibilité › Measuring DNA mechanics on the genome scale.
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › Measuring DNA mechanics on the genome scale.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Protéines de Saccharomyces cerevisiae › Measuring DNA mechanics on the genome scale.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Site d'initiation de la transcription › Measuring DNA mechanics on the genome scale.