Alcohol use and tuberculosis clinical presentation at the time of diagnosis in Puducherry and Tamil Nadu, India.
Adolescent
Adult
Alcohol Drinking
/ adverse effects
Alcoholism
/ complications
Female
Humans
India
Lung
/ diagnostic imaging
Male
Middle Aged
Mycobacterium tuberculosis
/ isolation & purification
Prospective Studies
Radiography
Risk Factors
Severity of Illness Index
Tuberculosis, Pulmonary
/ diagnosis
Young Adult
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
27
07
2020
accepted:
30
09
2020
entrez:
17
12
2020
pubmed:
18
12
2020
medline:
20
1
2021
Statut:
epublish
Résumé
Alcohol use increases the risk of tuberculosis (TB) disease and is associated with worse outcomes. To determine whether alcohol use affects TB severity at diagnosis in a high-burden setting. Participants were smear-positive people living with TB (PLWTB) in India. Disease severity was assessed as 1) high versus low smear grade, 2) time to positivity (TTP) on liquid culture, 3) chest radiograph cavitation, and 4) percent lung affected. Alcohol use and being at-risk for alcohol use disorders (AUD) were assessed using the AUDIT-C. Univariable and multivariable analyses were conducted. Of 1166 PLWTB, 691 (59.3%) were drinkers; of those, 518/691 (75.0%) were at-risk for AUD. Drinkers had more lung affected than non-drinkers (adjusted mean difference 10.8%, p<0.0001); this was not significant for those at-risk for AUD (adjusted mean difference 3.7%, p = 0.11). High smear grade (aOR 1.0, 95%CI: 0.7-1.4), cavitation (aOR 0.8, 95%CI 0.4-1.8), and TTP (mean difference 5.2 hours, p = 0.51) did not differ between drinkers and non-drinkers, nor between those at-risk and not at-risk for AUD. A large proportion of PLWTB were drinkers and were at-risk for AUD. Alcohol drinkers had more lung affected than non-drinkers. Studies are needed to explore mechanisms of this association.
Identifiants
pubmed: 33332367
doi: 10.1371/journal.pone.0240595
pii: PONE-D-20-23355
pmc: PMC7746146
doi:
Types de publication
Journal Article
Observational Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0240595Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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