Sentinel lymph node mapping with indocyanine green compared to blue dye tracer in gynecologic malignancies-A single center experience of 218 patients.
Adult
Aged
Aged, 80 and over
Coloring Agents
/ pharmacokinetics
Female
Follow-Up Studies
Genital Neoplasms, Female
/ diagnostic imaging
Humans
Indocyanine Green
/ pharmacokinetics
Middle Aged
Prognosis
Retrospective Studies
Rosaniline Dyes
/ pharmacokinetics
Sentinel Lymph Node
/ diagnostic imaging
Sentinel Lymph Node Biopsy
Tissue Distribution
cervical cancer
detection rate
endometrial cancer
systematic lymph node detection
Journal
Journal of surgical oncology
ISSN: 1096-9098
Titre abrégé: J Surg Oncol
Pays: United States
ID NLM: 0222643
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
25
07
2020
revised:
08
11
2020
accepted:
30
11
2020
pubmed:
18
12
2020
medline:
11
3
2021
entrez:
17
12
2020
Statut:
ppublish
Résumé
To compare the detection rates of sentinel lymph nodes after converting the tracer technique from blue dye to indocyanine green (ICG). Patients with uterine or cervical cancer were enrolled for sentinel lymph node (SLN) dissection. A total of 109 consecutive patients were analyzed and compared to a historical cohort of 109 consecutive patients with the sentinel blue dye technique. SLNs were analyzed by ultrastaging. The bilateral mapping rate of sentinel nodes was significantly higher with the ICG (78%; n = 85) compared to the blue dye tracer (61%; n = 67; p = .006). Neither the mean number of SLN nor the rate of low volume metastases showed significant differences between both cohorts. In the subgroup of endometrial cancer patients, the number of systematic lymph node dissection (LND) was significantly lower in the ICG cohort compared to the blue dye cohort (9% vs. 28%, p = .001). ICG improved the detection rate of pelvic SLN compared to blue dye and may be considered as the superior technique. In clinical practice, the rate of systematic LND further decreased after incorporating SLN mapping with ICG. Reliable safety data are still pending.
Sections du résumé
BACKGROUND AND OBJECTIVES
OBJECTIVE
To compare the detection rates of sentinel lymph nodes after converting the tracer technique from blue dye to indocyanine green (ICG).
METHODS
METHODS
Patients with uterine or cervical cancer were enrolled for sentinel lymph node (SLN) dissection. A total of 109 consecutive patients were analyzed and compared to a historical cohort of 109 consecutive patients with the sentinel blue dye technique. SLNs were analyzed by ultrastaging.
RESULTS
RESULTS
The bilateral mapping rate of sentinel nodes was significantly higher with the ICG (78%; n = 85) compared to the blue dye tracer (61%; n = 67; p = .006). Neither the mean number of SLN nor the rate of low volume metastases showed significant differences between both cohorts. In the subgroup of endometrial cancer patients, the number of systematic lymph node dissection (LND) was significantly lower in the ICG cohort compared to the blue dye cohort (9% vs. 28%, p = .001).
CONCLUSIONS
CONCLUSIONS
ICG improved the detection rate of pelvic SLN compared to blue dye and may be considered as the superior technique. In clinical practice, the rate of systematic LND further decreased after incorporating SLN mapping with ICG. Reliable safety data are still pending.
Substances chimiques
Coloring Agents
0
Rosaniline Dyes
0
Indocyanine Green
IX6J1063HV
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1092-1098Informations de copyright
© 2020 Wiley Periodicals LLC.
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