A Plasma Proteomic Signature of Skeletal Muscle Mitochondrial Function.
Adult
Aged
Aged, 80 and over
Energy Metabolism
/ physiology
Female
Gene Ontology
Humans
Inflammation
/ blood
Magnetic Resonance Spectroscopy
Male
Middle Aged
Mitochondria
/ metabolism
Muscle, Skeletal
/ metabolism
Oxidative Stress
/ physiology
Plasma
/ metabolism
Proteome
/ metabolism
Proteomics
Reactive Oxygen Species
/ metabolism
SOMAscan
aptamers
inflammation
mitochondria
oxidative capacity
phosphorous magnetic resonance spectroscopy
plasma
proteomics
skeletal muscle
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
15 Dec 2020
15 Dec 2020
Historique:
received:
31
10
2020
revised:
09
12
2020
accepted:
10
12
2020
entrez:
18
12
2020
pubmed:
19
12
2020
medline:
20
3
2021
Statut:
epublish
Résumé
Although mitochondrial dysfunction has been implicated in aging, physical function decline, and several age-related diseases, an accessible and affordable measure of mitochondrial health is still lacking. In this study we identified the proteomic signature of muscular mitochondrial oxidative capacity in plasma. In 165 adults, we analyzed the association between concentrations of plasma proteins, measured using the SOMAscan assay, and skeletal muscle maximal oxidative phosphorylation capacity assessed as post-exercise phosphocreatine recovery time constant (τ
Identifiants
pubmed: 33333910
pii: ijms21249540
doi: 10.3390/ijms21249540
pmc: PMC7765442
pii:
doi:
Substances chimiques
Proteome
0
Reactive Oxygen Species
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
ID : R01 AG057723
Pays : United States
Organisme : NIH HHS
ID : R01 AG057723
Pays : United States
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