Angiopoietin-2 Promotes Inflammatory Activation in Monocytes of Systemic Sclerosis Patients.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
15 Dec 2020
Historique:
received: 20 10 2020
revised: 04 12 2020
accepted: 11 12 2020
entrez: 18 12 2020
pubmed: 19 12 2020
medline: 16 3 2021
Statut: epublish

Résumé

Angiopoietin-2 (Ang-2), a ligand of the tyrosine kinase receptor Tie2, is essential for vascular development and blood vessel stability and is also involved in monocyte activation. Here, we examined the role of Ang-2 on monocyte activation in patients with systemic sclerosis (SSc). Ang-2 levels were measured in serum and skin of healthy controls (HCs) and SSc patients by ELISA and array profiling, respectively. mRNA expression of

Identifiants

pubmed: 33333969
pii: ijms21249544
doi: 10.3390/ijms21249544
pmc: PMC7765391
pii:
doi:

Substances chimiques

ANGPT2 protein, human 0
Angiopoietin-2 0
Biomarkers 0
Cytokines 0
Inflammation Mediators 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Références

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Auteurs

Tiago Carvalheiro (T)

Center for Translational Immunology, University Medical Center Utrecht, University of Utrecht, 3508 GA Utrecht, The Netherlands.
Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, University of Utrecht, 3584 CX Utrecht, The Netherlands.

Ana P Lopes (AP)

Center for Translational Immunology, University Medical Center Utrecht, University of Utrecht, 3508 GA Utrecht, The Netherlands.
Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, University of Utrecht, 3584 CX Utrecht, The Netherlands.

Maarten van der Kroef (M)

Center for Translational Immunology, University Medical Center Utrecht, University of Utrecht, 3508 GA Utrecht, The Netherlands.
Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, University of Utrecht, 3584 CX Utrecht, The Netherlands.

Beatriz Malvar-Fernandez (B)

Center for Translational Immunology, University Medical Center Utrecht, University of Utrecht, 3508 GA Utrecht, The Netherlands.
Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, University of Utrecht, 3584 CX Utrecht, The Netherlands.

Carlos Rafael-Vidal (C)

Rheumatology & Immuno-mediated Diseases Research Group (IRIDIS), Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36312 Vigo, Spain.
Rheumatology Department, University Hospital Complex of Vigo, 36313 Vigo, Spain.

Anneline C Hinrichs (AC)

Center for Translational Immunology, University Medical Center Utrecht, University of Utrecht, 3508 GA Utrecht, The Netherlands.
Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, University of Utrecht, 3584 CX Utrecht, The Netherlands.

Nila H Servaas (NH)

Center for Translational Immunology, University Medical Center Utrecht, University of Utrecht, 3508 GA Utrecht, The Netherlands.
Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, University of Utrecht, 3584 CX Utrecht, The Netherlands.

Femke Bonte-Mineur (F)

Department of Rheumatology and Clinical Immunology, Maasstad Hospital Rotterdam, 3079 DZ Rotterdam, The Netherlands.

Marc R Kok (MR)

Department of Rheumatology and Clinical Immunology, Maasstad Hospital Rotterdam, 3079 DZ Rotterdam, The Netherlands.

Lorenzo Beretta (L)

Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, 20122 Milan, Italy.

Maili Zimmermann (M)

Center for Translational Immunology, University Medical Center Utrecht, University of Utrecht, 3508 GA Utrecht, The Netherlands.
Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, University of Utrecht, 3584 CX Utrecht, The Netherlands.

Wioleta Marut (W)

Center for Translational Immunology, University Medical Center Utrecht, University of Utrecht, 3508 GA Utrecht, The Netherlands.
Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, University of Utrecht, 3584 CX Utrecht, The Netherlands.

Jose M Pego-Reigosa (JM)

Rheumatology & Immuno-mediated Diseases Research Group (IRIDIS), Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36312 Vigo, Spain.
Rheumatology Department, University Hospital Complex of Vigo, 36313 Vigo, Spain.

Timothy R D J Radstake (TRDJ)

Center for Translational Immunology, University Medical Center Utrecht, University of Utrecht, 3508 GA Utrecht, The Netherlands.
Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, University of Utrecht, 3584 CX Utrecht, The Netherlands.

Samuel Garcia (S)

Center for Translational Immunology, University Medical Center Utrecht, University of Utrecht, 3508 GA Utrecht, The Netherlands.
Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, University of Utrecht, 3584 CX Utrecht, The Netherlands.
Rheumatology & Immuno-mediated Diseases Research Group (IRIDIS), Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36312 Vigo, Spain.
Rheumatology Department, University Hospital Complex of Vigo, 36313 Vigo, Spain.

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