Optimization of Versatile Oxindoles as Selective PI3Kδ Inhibitors.
Journal
ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073
Informations de publication
Date de publication:
10 Dec 2020
10 Dec 2020
Historique:
received:
12
08
2020
accepted:
17
11
2020
entrez:
18
12
2020
pubmed:
19
12
2020
medline:
19
12
2020
Statut:
epublish
Résumé
The 3,3-disubstituted oxindole moiety is a versatile and rigid three-dimensionally shaped scaffold. When engineered with a purine hinge-binding core, exceptionally selective PI3Kδ kinase inhibitors were discovered by exploiting small differences in isoform selectivity pockets. Crystal structures of early lead
Identifiants
pubmed: 33335668
doi: 10.1021/acsmedchemlett.0c00441
pmc: PMC7734802
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2461-2469Informations de copyright
© 2020 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
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