Decoding capsule synthesis in Streptococcus pneumoniae.
Streptococcus pneumoniae
capsular polysaccharides
capsule
cell surface
vaccine development
Journal
FEMS microbiology reviews
ISSN: 1574-6976
Titre abrégé: FEMS Microbiol Rev
Pays: England
ID NLM: 8902526
Informations de publication
Date de publication:
17 08 2021
17 08 2021
Historique:
received:
10
06
2020
accepted:
07
12
2020
pubmed:
19
12
2020
medline:
2
2
2022
entrez:
18
12
2020
Statut:
ppublish
Résumé
Streptococcus pneumoniae synthesizes >100 types of capsular polysaccharides (CPSs). While the diversity of the enzymes and transporters involved is enormous, it is not limitless. In this review, we summarized the recent progress on elucidating the structure-function relationships of CPSs, the mechanisms by which they are synthesized, how their synthesis is regulated, the host immune response against them and the development of novel pneumococcal vaccines. Based on the genetic and structural information available, we generated provisional models of the CPS repeating units that remain unsolved. In addition, to facilitate cross-species comparisons and assignment of glycosyltransferases, we illustrated the biosynthetic pathways of the known CPSs in a standardized format. Studying the intricate steps of pneumococcal CPS assembly promises to provide novel insights for drug and vaccine development as well as improve our understanding of related pathways in other species.
Identifiants
pubmed: 33338218
pii: 6041728
doi: 10.1093/femsre/fuaa067
pii:
doi:
Substances chimiques
Pneumococcal Vaccines
0
Polysaccharides, Bacterial
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National University of Singapore
ID : NUHSRO/2017/070/SU/01
Organisme : National Research Foundation Singapore
Organisme : Singapore National Research Foundation
ID : NRF-NRFF-2019-0005
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of FEMS. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.