Aerosol generation during chest compression and defibrillation in a swine cardiac arrest model.
Aerosol generation
COVID-19
Cardiac arrest
Cardiopulmonary resuscitation
Chest compression
Defibrillation
SARS-CoV-2
Swine model
Journal
Resuscitation
ISSN: 1873-1570
Titre abrégé: Resuscitation
Pays: Ireland
ID NLM: 0332173
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
20
09
2020
revised:
04
11
2020
accepted:
01
12
2020
pubmed:
19
12
2020
medline:
20
2
2021
entrez:
18
12
2020
Statut:
ppublish
Résumé
It remains unclear whether cardiac arrest (CA) resuscitation generates aerosols that can transmit respiratory pathogens. We hypothesize that chest compression and defibrillation generate aerosols that could contain the SARS-CoV-2 virus in a swine CA model. To simulate witnessed CA with bystander-initiated cardiopulmonary resuscitation, 3 female non-intubated swine underwent 4 min of ventricular fibrillation without chest compression or defibrillation (no-flow) followed by ten 2-min cycles of mechanical chest compression and defibrillation without ventilation. The diameter (0.3-10 μm) and quantity of aerosols generated during 45-s intervals of no-flow and chest compression before and after defibrillation were analyzed by a particle analyzer. Aerosols generated from the coughs of 4 healthy human subjects were also compared to aerosols generated by swine. There was no significant difference between the total aerosols generated during chest compression before defibrillation compared to no-flow. In contrast, chest compression after defibrillation generated significantly more aerosols than chest compression before defibrillation or no-flow (72.4 ± 41.6 × 10 Chest compressions alone did not cause significant aerosol generation in this swine model. However, increased aerosol generation was detected during chest compression immediately following defibrillation. Additional research is needed to elucidate the clinical significance and mechanisms by which aerosol generation during chest compression is modified by defibrillation.
Identifiants
pubmed: 33338570
pii: S0300-9572(20)30598-0
doi: 10.1016/j.resuscitation.2020.12.004
pmc: PMC7833865
pii:
doi:
Substances chimiques
Aerosols
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
28-34Subventions
Organisme : NHLBI NIH HHS
ID : K12 HL133304
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL133129
Pays : United States
Organisme : NHLBI NIH HHS
ID : R34 HL130738
Pays : United States
Organisme : NHLBI NIH HHS
ID : R44 HL091606
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
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