DNA Repair Biosensor-Identified DNA Damage Activities of Endophyte Extracts from
Animals
Biosensing Techniques
Cell Line
Cell Survival
Chickens
DNA Breaks, Double-Stranded
DNA Damage
DNA End-Joining Repair
DNA Helicases
/ metabolism
DNA Repair
DNA-Binding Proteins
/ metabolism
Endophytes
/ chemistry
Fermentation
Fungi
/ metabolism
Garcinia
/ metabolism
Histones
/ metabolism
Homologous Recombination
Plant Extracts
/ pharmacology
Plants, Medicinal
Seeds
/ metabolism
Tumor Suppressor p53-Binding Protein 1
/ metabolism
DNA damage and repair
Garcinia cowa Roxb. ex Choisy
biosensor
cancer
endophyte
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
16 12 2020
16 12 2020
Historique:
received:
02
10
2020
revised:
04
12
2020
accepted:
10
12
2020
entrez:
19
12
2020
pubmed:
20
12
2020
medline:
14
9
2021
Statut:
epublish
Résumé
Recent developments in chemotherapy focus on target-specific mechanisms, which occur only in cancer cells and minimize the effects on normal cells. DNA damage and repair pathways are a promising target in the treatment of cancer. In order to identify novel compounds targeting DNA repair pathways, two key proteins, 53BP1 and RAD54L, were tagged with fluorescent proteins as indicators for two major double strand break (DSB) repair pathways: non-homologous end-joining (NHEJ) and homologous recombination (HR). The engineered biosensor cells exhibited the same DNA repair properties as the wild type. The biosensor cells were further used to investigate the DNA repair activities of natural biological compounds. An extract from
Identifiants
pubmed: 33339185
pii: biom10121680
doi: 10.3390/biom10121680
pmc: PMC7765599
pii:
doi:
Substances chimiques
DNA-Binding Proteins
0
H2AX protein, human
0
Histones
0
Plant Extracts
0
Tumor Suppressor p53-Binding Protein 1
0
DNA Helicases
EC 3.6.4.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Mahidol University
ID : na
Pays : International
Organisme : RGJ-Advanced
ID : RAP61K0007
Pays : International
Organisme : Faculty of Medicine Ramathibodi Hospital, Mahidol University
ID : RA scholarship
Pays : International
Organisme : Advanced Research on Pharmacology Fund; Siriraj Foundation
ID : D003421
Pays : International
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