Functional Complexes of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Receptors: Expression in Adult but Not Fetal Lung Tissue.
Adult
Angiotensin-Converting Enzyme 2
/ metabolism
COVID-19
/ pathology
Cell Line
Chemokine CXCL12
/ metabolism
HEK293 Cells
Humans
Peptidyl-Dipeptidase A
/ metabolism
Proto-Oncogene Mas
Proto-Oncogene Proteins
/ metabolism
Receptor, Angiotensin, Type 1
/ metabolism
Receptor, Angiotensin, Type 2
/ metabolism
Receptors, CXCR4
/ metabolism
Receptors, G-Protein-Coupled
/ metabolism
Receptors, Virus
/ metabolism
Renin-Angiotensin System
/ physiology
SARS-CoV-2
/ metabolism
Signal Transduction
/ physiology
ACE2
COVID-19
Mas receptor
RAS
SARS-CoV-2 receptor
angiotensin receptor
lung
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
16 Dec 2020
16 Dec 2020
Historique:
received:
14
11
2020
revised:
04
12
2020
accepted:
11
12
2020
entrez:
19
12
2020
pubmed:
20
12
2020
medline:
29
12
2020
Statut:
epublish
Résumé
Angiotensin-converting enzyme 2 (ACE2) is a membrane peptidase and a component of the renin-angiotensin system (RAS) that has been found in cells of all organs, including the lungs. While ACE2 has been identified as the receptor for severe acute respiratory syndrome (SARS) coronaviruses, the mechanism underlying cell entry remains unknown. Human immunodeficiency virus infects target cells via CXC chemokine receptor 4 (CXCR4)-mediated endocytosis. Furthermore, CXCR4 interacts with dipeptidyl peptidase-4 (CD26/DPPIV), an enzyme that cleaves CXCL12/SDF-1, which is the chemokine that activates this receptor. By analogy, we hypothesized that ACE2 might also be capable of interactions with RAS-associated G-protein coupled receptors. Using resonance energy transfer and cAMP and mitogen-activated protein kinase signaling assays, we found that human ACE2 interacts with RAS-related receptors, namely the angiotensin II type 1 receptor (AT
Identifiants
pubmed: 33339432
pii: ijms21249602
doi: 10.3390/ijms21249602
pmc: PMC7766085
pii:
doi:
Substances chimiques
CXCL12 protein, human
0
CXCR4 protein, human
0
Chemokine CXCL12
0
MAS1 protein, human
0
Mas1 protein, mouse
0
Proto-Oncogene Mas
0
Proto-Oncogene Proteins
0
Receptor, Angiotensin, Type 1
0
Receptor, Angiotensin, Type 2
0
Receptors, CXCR4
0
Receptors, G-Protein-Coupled
0
Receptors, Virus
0
Peptidyl-Dipeptidase A
EC 3.4.15.1
ACE2 protein, human
EC 3.4.17.23
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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