Wound Healing-related Functions of the p160 Steroid Receptor Coactivator Family.
Animals
Gene Expression Regulation
Humans
Multigene Family
/ physiology
Neovascularization, Physiologic
/ genetics
Nuclear Receptor Coactivator 1
/ physiology
Nuclear Receptor Coactivator 2
/ physiology
Nuclear Receptor Coactivator 3
/ physiology
Nuclear Receptor Coactivators
/ physiology
Signal Transduction
/ genetics
Wound Healing
/ genetics
myocardial infarction
p160 steroid receptor co-activator
wound healing
Journal
Endocrinology
ISSN: 1945-7170
Titre abrégé: Endocrinology
Pays: United States
ID NLM: 0375040
Informations de publication
Date de publication:
01 03 2021
01 03 2021
Historique:
received:
03
11
2020
pubmed:
20
12
2020
medline:
11
9
2021
entrez:
19
12
2020
Statut:
ppublish
Résumé
Multicellular organisms have evolved sophisticated mechanisms to recover and maintain original tissue functions following injury. Injury responses require a robust transcriptomic response associated with cellular reprogramming involving complex gene expression programs critical for effective tissue repair following injury. Steroid receptor coactivators (SRCs) are master transcriptional regulators of cell-cell signaling that is integral for embryogenesis, reproduction, normal physiological function, and tissue repair following injury. Effective therapeutic approaches for facilitating improved tissue regeneration and repair will likely involve temporal and combinatorial manipulation of cell-intrinsic and cell-extrinsic factors. Pleiotropic actions of SRCs that are critical for wound healing range from immune regulation and angiogenesis to maintenance of metabolic regulation in diverse organ systems. Recent evidence derived from studies of model organisms during different developmental stages indicates the importance of the interplay of immune cells and stromal cells to wound healing. With SRCs being the master regulators of cell-cell signaling integral to physiologic changes necessary for wound repair, it is becoming clear that therapeutic targeting of SRCs provides a unique opportunity for drug development in wound healing. This review will provide an overview of wound healing-related functions of SRCs with a special focus on cellular and molecular interactions important for limiting tissue damage after injury. Finally, we review recent findings showing stimulation of SRCs following cardiac injury with the SRC small molecule stimulator MCB-613 can promote cardiac protection and inhibit pathologic remodeling after myocardial infarction.
Identifiants
pubmed: 33340403
pii: 6042238
doi: 10.1210/endocr/bqaa232
pmc: PMC7814297
pii:
doi:
Substances chimiques
Nuclear Receptor Coactivator 2
0
Nuclear Receptor Coactivators
0
Nuclear Receptor Coactivator 1
EC 2.3.1.48
Nuclear Receptor Coactivator 3
EC 2.3.1.48
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NICHD NIH HHS
ID : F32 HD008188
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD007857
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD008188
Pays : United States
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of the Endocrine Society.
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