Measuring acetyl-CoA and acetylated histone turnover in vivo: Effect of a high fat diet.
Acetyl Coenzyme A
/ metabolism
Acetylation
Animals
Deuterium Oxide
/ administration & dosage
Diet, High-Fat
/ adverse effects
Histones
/ metabolism
Humans
Liver
/ metabolism
Lysine
/ metabolism
Male
Mass Spectrometry
Mice
Non-alcoholic Fatty Liver Disease
/ metabolism
Protein Processing, Post-Translational
Acetyl-CoA
Acetylation
Heavy water
High resolution mass spectrometry
Histone
Turnover
Journal
Analytical biochemistry
ISSN: 1096-0309
Titre abrégé: Anal Biochem
Pays: United States
ID NLM: 0370535
Informations de publication
Date de publication:
15 02 2021
15 02 2021
Historique:
received:
10
08
2020
revised:
08
12
2020
accepted:
13
12
2020
pubmed:
20
12
2020
medline:
23
6
2021
entrez:
19
12
2020
Statut:
ppublish
Résumé
Cellular availability of acetyl-CoA, a central intermediate of metabolism, regulates histone acetylation. The impact of a high-fat diet (HFD) on the turnover rates of acetyl-CoA and acetylated histones is unknown. We developed a method for simultaneous measurement of acetyl-CoA and acetylated histones kinetics using a single
Identifiants
pubmed: 33340539
pii: S0003-2697(20)30599-6
doi: 10.1016/j.ab.2020.114067
pii:
doi:
Substances chimiques
Histones
0
Acetyl Coenzyme A
72-89-9
Deuterium Oxide
J65BV539M3
Lysine
K3Z4F929H6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
114067Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM112044
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL129120
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK097771
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.