Fatty acid ethyl esters in meconium and substance use in adolescence.
Adolescent
Adolescent Behavior
Adult
Alcohol Drinking
/ metabolism
Biomarkers
/ metabolism
Cognition
Cohort Studies
Esterification
Esters
/ metabolism
Ethanol
/ metabolism
Fatty Acids
/ chemistry
Female
Fetal Alcohol Spectrum Disorders
/ etiology
Humans
Infant, Newborn
Longitudinal Studies
Male
Meconium
/ metabolism
Pregnancy
Prenatal Exposure Delayed Effects
/ metabolism
Prospective Studies
Substance-Related Disorders
/ etiology
Young Adult
Adolescent substance use
Alcohol
Biomarker
FAEEs
Teratology
Journal
Neurotoxicology and teratology
ISSN: 1872-9738
Titre abrégé: Neurotoxicol Teratol
Pays: United States
ID NLM: 8709538
Informations de publication
Date de publication:
Historique:
received:
08
05
2020
revised:
10
12
2020
accepted:
13
12
2020
pubmed:
20
12
2020
medline:
21
10
2021
entrez:
19
12
2020
Statut:
ppublish
Résumé
Prenatal alcohol exposure (PAE) continues to be a serious public health problem, yet no reliable clinical tools are available for assessing levels of drinking during pregnancy. Fatty acid ethyl esters (FAEEs), the nonoxidative metabolites of ethanol measured in meconium, are potential biomarkers to quantify the level of PAE. The association between the concentrations of FAEEs from meconium and adolescent substance use and related problems was examined in a prospective birth-cohort of adolescents exposed to alcohol and drugs in utero. FAEEs were quantified with gas chromatography via a flame ionization detector. Meconium was analyzed for FAEEs in 216 newborns; 183 of them (81 boys, 102 girls) were assessed at age 15 for alcohol, tobacco, and marijuana use using biologic assays and self-report. Substance use problems were assessed using the Problem Oriented Screening Instrument for Teenagers. Findings from multivariable logistic regression analyses indicated that, after controlling for other prenatal drug exposure and covariates, higher concentrations of FAEEs (ethyl myristate, ethyl palmitate, ethyl oleate, ethyl linoleate, ethyl linolenate, and ethyl arachidonate) were related to a greater likelihood of marijuana use and experiencing substance use problems, but not tobacco or alcohol use, at age 15. Elevated levels of FAEEs in meconium may be promising markers for PAE, identifying newborns at risk for early substance use and developing substance use problems.
Identifiants
pubmed: 33340653
pii: S0892-0362(20)30196-3
doi: 10.1016/j.ntt.2020.106946
pmc: PMC7855880
mid: NIHMS1657554
pii:
doi:
Substances chimiques
Biomarkers
0
Esters
0
Fatty Acids
0
Ethanol
3K9958V90M
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
106946Subventions
Organisme : NIDA NIH HHS
ID : R01 DA007957
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA042747
Pays : United States
Organisme : NIDA NIH HHS
ID : R34 DA050342
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002548
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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