Comparing spontaneous and stimulus frequency otoacoustic emissions in mice with tectorial membrane defects.

Animals Deafness Hearing Mice Mutation, Missense Otoacoustic Emissions, Spontaneous Tectorial Membrane
Ceacam16 Cochlea Otoancorin Spontaneous otoacoustic emissions Tecta Tectorial membrane

Journal

Hearing research
ISSN: 1878-5891
Titre abrégé: Hear Res
Pays: Netherlands
ID NLM: 7900445

Informations de publication

Date de publication:
02 2021
Historique:
received: 24 07 2020
revised: 20 11 2020
accepted: 02 12 2020
pubmed: 20 12 2020
medline: 4 2 2022
entrez: 19 12 2020
Statut: ppublish

Résumé

The global standing-wave model for generation of spontaneous otoacoustic emissions (SOAEs) suggests that they are amplitude-stabilized standing waves and that the spacing between SOAEs corresponds to the interval over which the phase changes by one cycle as determined from the phase-gradient delays of stimulus frequency otoacoustic emissions (SFOAEs). Because data characterizing the relationship between spontaneous and evoked emissions in nonhuman mammals are limited, we examined SOAEs and SFOAEs in tectorial membrane (TM) mutants and their controls. Computations indicate that the spacing between adjacent SOAEs is predicted by the SFOAE phase-gradient delays for TM mutants lacking Ceacam16, where SOAE frequencies are greater than ~20 kHz and the mutants retain near-normal hearing when young. Mice with a missense mutation in Tecta (Tecta

Identifiants

DOI: 10.1016/j.heares.2020.108143 PMID: 33340968 PMC: PMC7796953
pubmed: 33340968
pii: S0378-5955(20)30414-7
doi: 10.1016/j.heares.2020.108143
pmc: PMC7796953
mid: NIHMS1652487
pii:
doi:

Types de publication

Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

108143

Subventions

Organisme : NIDCD NIH HHS
ID : R01 DC000089
Pays : United States

Informations de copyright

Copyright © 2020. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The author declares no conflict of interest.

Auteurs

Mary Ann Cheatham (MA)

The Knowles Hearing Center, Roxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, 2-240 Frances Searle Building, 2240 Campus Drive, Evanston IL 60208, USA. Electronic address: m-cheatham@northwestern.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Comparing spontaneous and stimulus frequency...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Troubles sensitifs › Troubles de l'audition › Perte d'audition › Surdité › Comparing spontaneous and stimulus frequency...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sensation › Ouïe › Comparing spontaneous and stimulus frequency...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Comparing spontaneous and stimulus frequency...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutation faux-sens › Comparing spontaneous and stimulus frequency...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sensation › Ouïe › Émissions otoacoustiques spontanées › Comparing spontaneous and stimulus frequency...
questionsmedicales.fr › Organes des sens › Oreille › Oreille interne › Cochlée › Conduit cochléaire › Membrane tectoriale › Comparing spontaneous and stimulus frequency...