SARS-CoV-2 hot-spot mutations are significantly enriched within inverted repeats and CpG island loci.
CpG methylation
SARS-CoV-2
hot spot
inverted repeats
Journal
Briefings in bioinformatics
ISSN: 1477-4054
Titre abrégé: Brief Bioinform
Pays: England
ID NLM: 100912837
Informations de publication
Date de publication:
22 03 2021
22 03 2021
Historique:
received:
16
07
2020
revised:
16
11
2020
accepted:
27
11
2020
pubmed:
21
12
2020
medline:
15
4
2021
entrez:
20
12
2020
Statut:
ppublish
Résumé
SARS-CoV-2 is an intensively investigated virus from the order Nidovirales (Coronaviridae family) that causes COVID-19 disease in humans. Through enormous scientific effort, thousands of viral strains have been sequenced to date, thereby creating a strong background for deep bioinformatics studies of the SARS-CoV-2 genome. In this study, we inspected high-frequency mutations of SARS-CoV-2 and carried out systematic analyses of their overlay with inverted repeat (IR) loci and CpG islands. The main conclusion of our study is that SARS-CoV-2 hot-spot mutations are significantly enriched within both IRs and CpG island loci. This points to their role in genomic instability and may predict further mutational drive of the SARS-CoV-2 genome. Moreover, CpG islands are strongly enriched upstream from viral ORFs and thus could play important roles in transcription and the viral life cycle. We hypothesize that hypermethylation of these loci will decrease the transcription of viral ORFs and could therefore limit the progression of the disease.
Identifiants
pubmed: 33341900
pii: 6042389
doi: 10.1093/bib/bbaa385
pmc: PMC7799342
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1338-1345Informations de copyright
© The Author(s) 2020. Published by Oxford University Press.