Sex differences in parent-offspring recurrence of attention-deficit/hyperactivity disorder.

Attention Deficit Disorder with Hyperactivity / epidemiology Depressive Disorder, Major Fathers Female Humans Male Norway / epidemiology Parents Risk Factors Sex Characteristics
Attention-deficit/hyperactivity disorder epidemiology intergenerational recurrence risk parent-of-origin sex differences

Journal

Journal of child psychology and psychiatry, and allied disciplines
ISSN: 1469-7610
Titre abrégé: J Child Psychol Psychiatry
Pays: England
ID NLM: 0375361

Informations de publication

Date de publication:
08 2021
Historique:
revised: 21 11 2020
received: 09 07 2020
accepted: 25 11 2020
pubmed: 21 12 2020
medline: 21 10 2021
entrez: 20 12 2020
Statut: ppublish

Résumé

Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable neurodevelopmental disorder sharing genetic risk factors with other common psychiatric disorders. However, intergenerational recurrence patterns of ADHD from parents to sons and daughters are not known. We aimed to examine the risk of ADHD in offspring of parents with ADHD and parents with other psychiatric disorders by parental and offspring sex, using parents without the specific disorders as comparison. In a generation study linking data from several population-based registries, all Norwegians born 1967-2011 (n = 2,486,088; Medical Birth Registry of Norway) and their parents were followed to 2015. To estimate intergenerational recurrence risk, we calculated prevalence differences (PD) and the relative risk (RR) of ADHD in offspring by parental ADHD, bipolar disorder (BD), schizophrenia spectrum disorder (SCZ), major depression (MDD), all by parental and offspring sex. The absolute prevalence of ADHD in offspring of parents with ADHD was very high, especially in sons of two affected parents (41.5% and 25.1% in sons and daughters, respectively), and far higher than in offspring of parents with BD, SCZ or MDD. Intergenerational recurrence risks were higher for maternal than paternal ADHD (RR The intergenerational recurrence risks of ADHD were high and higher from mothers with ADHD than fathers with ADHD. Other parental psychiatric disorders also conferred increased risk of offspring ADHD, but far lower, indicating a sex- and diagnosis-specific intergenerational recurrence risk in parents with ADHD.

Sections du résumé

BACKGROUND
Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable neurodevelopmental disorder sharing genetic risk factors with other common psychiatric disorders. However, intergenerational recurrence patterns of ADHD from parents to sons and daughters are not known. We aimed to examine the risk of ADHD in offspring of parents with ADHD and parents with other psychiatric disorders by parental and offspring sex, using parents without the specific disorders as comparison.
METHODS
In a generation study linking data from several population-based registries, all Norwegians born 1967-2011 (n = 2,486,088; Medical Birth Registry of Norway) and their parents were followed to 2015. To estimate intergenerational recurrence risk, we calculated prevalence differences (PD) and the relative risk (RR) of ADHD in offspring by parental ADHD, bipolar disorder (BD), schizophrenia spectrum disorder (SCZ), major depression (MDD), all by parental and offspring sex.
RESULTS
The absolute prevalence of ADHD in offspring of parents with ADHD was very high, especially in sons of two affected parents (41.5% and 25.1% in sons and daughters, respectively), and far higher than in offspring of parents with BD, SCZ or MDD. Intergenerational recurrence risks were higher for maternal than paternal ADHD (RR
CONCLUSIONS
The intergenerational recurrence risks of ADHD were high and higher from mothers with ADHD than fathers with ADHD. Other parental psychiatric disorders also conferred increased risk of offspring ADHD, but far lower, indicating a sex- and diagnosis-specific intergenerational recurrence risk in parents with ADHD.

Identifiants

DOI: 10.1111/jcpp.13368 PMID: 33341963 PMC: PMC8451909
pubmed: 33341963
doi: 10.1111/jcpp.13368
pmc: PMC8451909
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1010-1018

Informations de copyright

© 2020 The Authors. Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health.

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Auteurs

Berit S Solberg (BS)

Department of Biomedicine, University of Bergen, Bergen, Norway.
Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Child and Adolescent Psychiatric Outpatient Unit, Hospital Betanien, Bergen, Norway.
ORCID: 0000-0002-0168-1675

Tor-Arne Hegvik (TA)

Department of Biomedicine, University of Bergen, Bergen, Norway.

Anne Halmøy (A)

Department of Psychiatry, Haukeland University Hospital, Bergen, Norway.
Department of Clinical Medicine, University of Bergen, Bergen, Norway.

Rolv Skjaerven (R)

Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.

Anders Engeland (A)

Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Division of Mental and Physical Health, Norwegian Institute of Public Health, Bergen, Norway.

Jan Haavik (J)

Department of Biomedicine, University of Bergen, Bergen, Norway.
Bergen Center for Brain Plasticity, Division of Psychiatry, Haukeland University Hospital, Bergen, Norway.

Kari Klungsøyr (K)

Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Division of Mental and Physical Health, Norwegian Institute of Public Health, Bergen, Norway.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles déficitaires de l'attention et du comportement perturbateur › Trouble déficitaire de l'attention avec hyperactivité › Sex differences in parent-offspring recurrence...
questionsmedicales.fr › Troubles mentaux › Troubles de l'humeur › Trouble dépressif › Trouble dépressif majeur › Sex differences in parent-offspring recurrence...
questionsmedicales.fr › Personnes › Parents › Pères › Sex differences in parent-offspring recurrence...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Sex differences in parent-offspring recurrence...
questionsmedicales.fr › Régions géographiques › Europe › Pays nordiques et scandinaves › Norvège › Sex differences in parent-offspring recurrence...
questionsmedicales.fr › Personnes › Parents › Sex differences in parent-offspring recurrence...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Sex differences in parent-offspring recurrence...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Caractères sexuels › Sex differences in parent-offspring recurrence...